Endoplasmic reticulum stress activates transglutaminase 2 leading to protein aggregation

Aberrant activation of transglutaminase 2 (TGase2) contributes to a variety of protein conformational disorders such as neurodegenerative diseases and age-related cataracts. The accumulation of improperly folded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR),...

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Detalles Bibliográficos
Autores principales: LEE, JIN-HAENG, JEONG, JAEHO, JEONG, EUI MAN, CHO, SUNG-YUP, KANG, JEONG WOOK, LIM, JISUN, HEO, JINBEOM, KANG, HYUNSOOK, KIM, IN-GYU, SHIN, DONG-MYUNG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976127/
https://www.ncbi.nlm.nih.gov/pubmed/24481335
http://dx.doi.org/10.3892/ijmm.2014.1640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976127/
https://www.ncbi.nlm.nih.gov/pubmed/24481335
http://dx.doi.org/10.3892/ijmm.2014.1640

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