Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue

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Mitochondrial DNA (mtDNA) contains unmethylated CpG motifs that exhibit immune stimulatory capacities. The aim of this study was to investigate whether mtDNA activates the Toll-like receptor 9 (TLR9)/nuclear factor-κB (NF-κB) pathway, thereby contributing to post-traumatic systemic inflammatory resp...

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Detalles Bibliográficos
Autores principales: ZHANG, JIAN-ZHENG, LIU, ZHI, LIU, JIA, REN, JI-XIN, SUN, TIAN-SHENG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976143/
https://www.ncbi.nlm.nih.gov/pubmed/24535292
http://dx.doi.org/10.3892/ijmm.2014.1650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976143/
https://www.ncbi.nlm.nih.gov/pubmed/24535292
http://dx.doi.org/10.3892/ijmm.2014.1650

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