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Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer

OBJECTIVE: To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer. METHODS: Eleven male patients (mean age 54.8 years) with newly diagnos...

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Autores principales: Kwee, Robert M., Dik, Alexander K., Sosef, Meindert N., Berendsen, Ralph C. M., Sassen, Sander, Lammering, Guido, Clarijs, Ruud, Oostenbrug, Liekele E., Blom, Rachel L. G. M., Vliegen, Roy F. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976260/
https://www.ncbi.nlm.nih.gov/pubmed/24704912
http://dx.doi.org/10.1371/journal.pone.0092211
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author Kwee, Robert M.
Dik, Alexander K.
Sosef, Meindert N.
Berendsen, Ralph C. M.
Sassen, Sander
Lammering, Guido
Clarijs, Ruud
Oostenbrug, Liekele E.
Blom, Rachel L. G. M.
Vliegen, Roy F. A.
author_facet Kwee, Robert M.
Dik, Alexander K.
Sosef, Meindert N.
Berendsen, Ralph C. M.
Sassen, Sander
Lammering, Guido
Clarijs, Ruud
Oostenbrug, Liekele E.
Blom, Rachel L. G. M.
Vliegen, Roy F. A.
author_sort Kwee, Robert M.
collection PubMed
description OBJECTIVE: To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer. METHODS: Eleven male patients (mean age 54.8 years) with newly diagnosed esophageal cancer underwent DW-MRI before and 10 days after start of chemoradiotherapy. Reproducibility of apparent diffusion coefficient (ADC) measurements by manual (freehand) and semi-automated volumetric methods was assessed. RESULTS: Interobserver reproducibility for the assessment of mean tumor ADC by the manual measurement method was good, with an ICC of 0.69 (95% CI, 0.36 to 0.85; P = 0.001). Interobserver reproducibility for the assessment of mean tumor ADC by the semi-automated volumetric measurement method was very good, with an ICC of 0.96 (95% CI, 0.91 to 0.98; P<0.001). CONCLUSION: Semi-automated volumetric ADC measurements have higher reproducibility than manual ADC measurements in assessing tumor response to chemoradiotherapy in patients with esophageal adenocarcinoma.
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spelling pubmed-39762602014-04-08 Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer Kwee, Robert M. Dik, Alexander K. Sosef, Meindert N. Berendsen, Ralph C. M. Sassen, Sander Lammering, Guido Clarijs, Ruud Oostenbrug, Liekele E. Blom, Rachel L. G. M. Vliegen, Roy F. A. PLoS One Research Article OBJECTIVE: To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer. METHODS: Eleven male patients (mean age 54.8 years) with newly diagnosed esophageal cancer underwent DW-MRI before and 10 days after start of chemoradiotherapy. Reproducibility of apparent diffusion coefficient (ADC) measurements by manual (freehand) and semi-automated volumetric methods was assessed. RESULTS: Interobserver reproducibility for the assessment of mean tumor ADC by the manual measurement method was good, with an ICC of 0.69 (95% CI, 0.36 to 0.85; P = 0.001). Interobserver reproducibility for the assessment of mean tumor ADC by the semi-automated volumetric measurement method was very good, with an ICC of 0.96 (95% CI, 0.91 to 0.98; P<0.001). CONCLUSION: Semi-automated volumetric ADC measurements have higher reproducibility than manual ADC measurements in assessing tumor response to chemoradiotherapy in patients with esophageal adenocarcinoma. Public Library of Science 2014-04-04 /pmc/articles/PMC3976260/ /pubmed/24704912 http://dx.doi.org/10.1371/journal.pone.0092211 Text en © 2014 Kwee et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kwee, Robert M.
Dik, Alexander K.
Sosef, Meindert N.
Berendsen, Ralph C. M.
Sassen, Sander
Lammering, Guido
Clarijs, Ruud
Oostenbrug, Liekele E.
Blom, Rachel L. G. M.
Vliegen, Roy F. A.
Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer
title Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer
title_full Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer
title_fullStr Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer
title_full_unstemmed Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer
title_short Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer
title_sort interobserver reproducibility of diffusion-weighted mri in monitoring tumor response to neoadjuvant therapy in esophageal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976260/
https://www.ncbi.nlm.nih.gov/pubmed/24704912
http://dx.doi.org/10.1371/journal.pone.0092211
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