Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

Changes in gene dosage are a major driver of cancer, engineered from a finite, but increasingly well annotated, repertoire of mutational mechanisms(1). This can potentially generate correlated copy number alterations across hundreds of linked genes, as exemplified by the 2% of childhood acute lympho...

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Detalles Bibliográficos
Autores principales: Li, Yilong, Schwab, Claire, Ryan, Sarra, Papaemmanuil, Elli, Robinson, Hazel M., Jacobs, Patricia, Moorman, Anthony V., Dyer, Sara, Borrow, Julian, Griffiths, Mike, Heerema, Nyla A., Carroll, Andrew J., Talley, Polly, Bown, Nick, Telford, Nick, Ross, Fiona M., Gaunt, Lorraine, McNally, Richard J. Q., Young, Bryan D., Sinclair, Paul, Rand, Vikki, Teixeira, Manuel R., Joseph, Olivia, Robinson, Ben, Maddison, Mark, Dastugue, Nicole, Vandenberghe, Peter, Stephens, Philip J., Cheng, Jiqiu, Van Loo, Peter, Stratton, Michael R., Campbell, Peter J., Harrison, Christine J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976272/
https://www.ncbi.nlm.nih.gov/pubmed/24670643
http://dx.doi.org/10.1038/nature13115

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