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AKT Inhibitors Promote Cell Death in Cervical Cancer through Disruption of mTOR Signaling and Glucose Uptake

BACKGROUND: PI3K/AKT pathway alterations are associated with incomplete response to chemoradiation in human cervical cancer. This study was performed to test for mutations in the PI3K pathway and to evaluate the effects of AKT inhibitors on glucose uptake and cell viability. EXPERIMENTAL DESIGN: Mut...

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Detalles Bibliográficos
Autores principales:	Rashmi, Ramachandran, DeSelm, Carl, Helms, Cynthia, Bowcock, Anne, Rogers, Buck E., Rader, Janet, Grigsby, Perry W., Schwarz, Julie K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976291/ https://www.ncbi.nlm.nih.gov/pubmed/24705275 http://dx.doi.org/10.1371/journal.pone.0092948

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