Deletion of Hypoxia-Inducible Factor-1α in Adipocytes Enhances Glucagon-Like Peptide-1 Secretion and Reduces Adipose Tissue Inflammation

It is known that obese adipose tissues are hypoxic and express hypoxia-inducible factor (HIF)-1α. Although some studies have shown that the expression of HIF-1α in adipocytes induces glucose intolerance, the mechanisms are still not clear. In this study, we examined its effects on the development of...

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Detalles Bibliográficos
Autores principales: Kihira, Yoshitaka, Miyake, Mariko, Hirata, Manami, Hoshina, Yoji, Kato, Kana, Shirakawa, Hitoshi, Sakaue, Hiroshi, Yamano, Noriko, Izawa-Ishizawa, Yuki, Ishizawa, Keisuke, Ikeda, Yasumasa, Tsuchiya, Koichiro, Tamaki, Toshiaki, Tomita, Shuhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976326/
https://www.ncbi.nlm.nih.gov/pubmed/24705496
http://dx.doi.org/10.1371/journal.pone.0093856

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