Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease

Mitochondria are no longer considered to be solely the static powerhouses of the cell. While they are undoubtedly essential to sustaining life and meeting the energy requirements of the cell through oxidative phosphorylation, they are now regarded as highly dynamic organelles with multiple funtions,...

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Detalles Bibliográficos
Autores principales: Hall, A R, Burke, N, Dongworth, R K, Hausenloy, D J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Ltd 2014
Materias:
Themed Issue: Mitochondrial Pharmacology: Energy, Injury & Beyond
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976611/
https://www.ncbi.nlm.nih.gov/pubmed/24328763
http://dx.doi.org/10.1111/bph.12516
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author Hall, A R
Burke, N
Dongworth, R K
Hausenloy, D J
author_facet Hall, A R
Burke, N
Dongworth, R K
Hausenloy, D J
author_sort Hall, A R
collection PubMed
description Mitochondria are no longer considered to be solely the static powerhouses of the cell. While they are undoubtedly essential to sustaining life and meeting the energy requirements of the cell through oxidative phosphorylation, they are now regarded as highly dynamic organelles with multiple funtions, playing key roles in cell survival and death. In this review, we discuss the emerging role of mitochondrial fusion and fission proteins, as novel therapeutic targets for treating a wide range of cardiovascular diseases. LINKED ARTICLES: This article is part of a themed issue on Mitochondrial Pharmacology: Energy, Injury & Beyond. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2014.171.issue-8
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spelling pubmed-39766112014-09-22 Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease Hall, A R Burke, N Dongworth, R K Hausenloy, D J Br J Pharmacol Themed Issue: Mitochondrial Pharmacology: Energy, Injury & Beyond Mitochondria are no longer considered to be solely the static powerhouses of the cell. While they are undoubtedly essential to sustaining life and meeting the energy requirements of the cell through oxidative phosphorylation, they are now regarded as highly dynamic organelles with multiple funtions, playing key roles in cell survival and death. In this review, we discuss the emerging role of mitochondrial fusion and fission proteins, as novel therapeutic targets for treating a wide range of cardiovascular diseases. LINKED ARTICLES: This article is part of a themed issue on Mitochondrial Pharmacology: Energy, Injury & Beyond. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2014.171.issue-8 John Wiley & Sons Ltd 2014-04 2014-03-28 /pmc/articles/PMC3976611/ /pubmed/24328763 http://dx.doi.org/10.1111/bph.12516 Text en © 2013 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Themed Issue: Mitochondrial Pharmacology: Energy, Injury & Beyond
Hall, A R
Burke, N
Dongworth, R K
Hausenloy, D J
Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease
title Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease
title_full Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease
title_fullStr Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease
title_full_unstemmed Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease
title_short Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease
title_sort mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease
topic Themed Issue: Mitochondrial Pharmacology: Energy, Injury & Beyond
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976611/
https://www.ncbi.nlm.nih.gov/pubmed/24328763
http://dx.doi.org/10.1111/bph.12516
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