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Exemestane blocks mesothelioma growth through downregulation of cAMP, pCREB and CD44 implicating new treatment option in patients affected by this disease
BACKGROUND: Recent evidence suggests that aromatase may be involved in the pathogenesis of malignant mesothelioma. Here, we evaluated the effect of exemestane, an inhibitor of aromatase, in the treatment of mesothelioma using in vitro and in vivo preclinical models. RESULTS: We show a significant re...
Autores principales: | Nuvoli, Barbara, Germoni, Sabrina, Morosetti, Carlotta, Santoro, Raffaela, Cortese, Giancarlo, Masi, Serena, Cordone, Iole, Galati, Rossella |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976636/ https://www.ncbi.nlm.nih.gov/pubmed/24655565 http://dx.doi.org/10.1186/1476-4598-13-69 |
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