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Outcome after intensity modulated radiotherapy for anaplastic thyroid carcinoma

BACKGROUND: Anaplastic thyroid carcinoma (ATC) is a malignancy with one of the highest fatality rates. We reviewed our recent clinical experience with intensity modulated radiotherapy (IMRT) combined with surgery and chemotherapy for the management of ATC. METHODS: 13 patients with ATC who were trea...

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Autores principales: He, Xiayun, Li, Duanshu, Hu, Chaosu, Wang, Zhuoying, Ying, Hongmei, Wu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976675/
https://www.ncbi.nlm.nih.gov/pubmed/24690325
http://dx.doi.org/10.1186/1471-2407-14-235
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author He, Xiayun
Li, Duanshu
Hu, Chaosu
Wang, Zhuoying
Ying, Hongmei
Wu, Yi
author_facet He, Xiayun
Li, Duanshu
Hu, Chaosu
Wang, Zhuoying
Ying, Hongmei
Wu, Yi
author_sort He, Xiayun
collection PubMed
description BACKGROUND: Anaplastic thyroid carcinoma (ATC) is a malignancy with one of the highest fatality rates. We reviewed our recent clinical experience with intensity modulated radiotherapy (IMRT) combined with surgery and chemotherapy for the management of ATC. METHODS: 13 patients with ATC who were treated by IMRT in our institution between October 2008 and February 2011, have been analyzed. The target volume for IMRT was planned to include Gross tumor volume (GTV): primary tumor plus any N + disease (66 Gy/33 F/6.6 W), with elective irradiation of thyroid bed, bilateral level II through VI and mediastinal lymph nodes to the level of the carina (54-60 Gy). Seven patients received surgical intervention and eleven patients had chemotherapy. RESULTS: The median radiotherapy dose to GTV was 60 Gy/30 fractions/6 weeks. The median survival time of the 13 patients was 9 months. The direct causes of death were distant metastases (75%) and progression of the locoregional disease (25%). Ten patients were spared dyspnea and tracheostomy because their primary neck lesion did not progress. CONCLUSION: The results showed that IMRT combined by surgery and chemotherapy for ATC might be beneficial to improve locoregional control. Further new therapies are needed to control metastases.
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spelling pubmed-39766752014-04-06 Outcome after intensity modulated radiotherapy for anaplastic thyroid carcinoma He, Xiayun Li, Duanshu Hu, Chaosu Wang, Zhuoying Ying, Hongmei Wu, Yi BMC Cancer Research Article BACKGROUND: Anaplastic thyroid carcinoma (ATC) is a malignancy with one of the highest fatality rates. We reviewed our recent clinical experience with intensity modulated radiotherapy (IMRT) combined with surgery and chemotherapy for the management of ATC. METHODS: 13 patients with ATC who were treated by IMRT in our institution between October 2008 and February 2011, have been analyzed. The target volume for IMRT was planned to include Gross tumor volume (GTV): primary tumor plus any N + disease (66 Gy/33 F/6.6 W), with elective irradiation of thyroid bed, bilateral level II through VI and mediastinal lymph nodes to the level of the carina (54-60 Gy). Seven patients received surgical intervention and eleven patients had chemotherapy. RESULTS: The median radiotherapy dose to GTV was 60 Gy/30 fractions/6 weeks. The median survival time of the 13 patients was 9 months. The direct causes of death were distant metastases (75%) and progression of the locoregional disease (25%). Ten patients were spared dyspnea and tracheostomy because their primary neck lesion did not progress. CONCLUSION: The results showed that IMRT combined by surgery and chemotherapy for ATC might be beneficial to improve locoregional control. Further new therapies are needed to control metastases. BioMed Central 2014-04-02 /pmc/articles/PMC3976675/ /pubmed/24690325 http://dx.doi.org/10.1186/1471-2407-14-235 Text en Copyright © 2014 He et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
He, Xiayun
Li, Duanshu
Hu, Chaosu
Wang, Zhuoying
Ying, Hongmei
Wu, Yi
Outcome after intensity modulated radiotherapy for anaplastic thyroid carcinoma
title Outcome after intensity modulated radiotherapy for anaplastic thyroid carcinoma
title_full Outcome after intensity modulated radiotherapy for anaplastic thyroid carcinoma
title_fullStr Outcome after intensity modulated radiotherapy for anaplastic thyroid carcinoma
title_full_unstemmed Outcome after intensity modulated radiotherapy for anaplastic thyroid carcinoma
title_short Outcome after intensity modulated radiotherapy for anaplastic thyroid carcinoma
title_sort outcome after intensity modulated radiotherapy for anaplastic thyroid carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976675/
https://www.ncbi.nlm.nih.gov/pubmed/24690325
http://dx.doi.org/10.1186/1471-2407-14-235
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