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Growth of the eye lens: II. Allometric studies

PURPOSE: The purpose of this study was to examine the ontogeny and phylogeny of lens growth in a variety of species using allometry. METHODS: Data on the accumulation of wet and/or dry lens weight as a function of bodyweight were obtained for 40 species and subjected to allometric analysis to examin...

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Autor principal: Augusteyn, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976690/
https://www.ncbi.nlm.nih.gov/pubmed/24715759
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author Augusteyn, Robert C.
author_facet Augusteyn, Robert C.
author_sort Augusteyn, Robert C.
collection PubMed
description PURPOSE: The purpose of this study was to examine the ontogeny and phylogeny of lens growth in a variety of species using allometry. METHODS: Data on the accumulation of wet and/or dry lens weight as a function of bodyweight were obtained for 40 species and subjected to allometric analysis to examine ontogenic growth and compaction. Allometric analysis was also used to compare the maximum adult lens weights for 147 species with the maximum adult bodyweight and to compare lens volumes calculated from wet and dry weights with eye volumes calculated from axial length. RESULTS: Linear allometric relationships were obtained for the comparison of ontogenic lens and bodyweight accumulation. The body mass exponent (BME) decreased with increasing animal size from around 1.0 in small rodents to 0.4 in large ungulates for both wet and dry weights. Compaction constants for the ontogenic growth ranged from 1.00 in birds and reptiles up to 1.30 in mammals. Allometric comparison of maximum lens wet and dry weights with maximum bodyweights also yielded linear plots with a BME of 0.504 for all warm blooded species except primates which had a BME of 0.25. When lens volumes were compared with eye volumes, all species yielded a scaling constant of 0.75 but the proportionality constants for primates and birds were lower. CONCLUSIONS: Ontogenic lens growth is fastest, relative to body growth, in small animals and slowest in large animals. Fiber cell compaction takes place throughout life in most species, but not in birds and reptiles. Maximum adult lens size scales with eye size with the same exponent in all species, but birds and primates have smaller lenses relative to eye size than other species. Optical properties of the lens are generated through the combination of variations in the rate of growth, rate of compaction, shape and size.
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spelling pubmed-39766902014-04-08 Growth of the eye lens: II. Allometric studies Augusteyn, Robert C. Mol Vis Research Article PURPOSE: The purpose of this study was to examine the ontogeny and phylogeny of lens growth in a variety of species using allometry. METHODS: Data on the accumulation of wet and/or dry lens weight as a function of bodyweight were obtained for 40 species and subjected to allometric analysis to examine ontogenic growth and compaction. Allometric analysis was also used to compare the maximum adult lens weights for 147 species with the maximum adult bodyweight and to compare lens volumes calculated from wet and dry weights with eye volumes calculated from axial length. RESULTS: Linear allometric relationships were obtained for the comparison of ontogenic lens and bodyweight accumulation. The body mass exponent (BME) decreased with increasing animal size from around 1.0 in small rodents to 0.4 in large ungulates for both wet and dry weights. Compaction constants for the ontogenic growth ranged from 1.00 in birds and reptiles up to 1.30 in mammals. Allometric comparison of maximum lens wet and dry weights with maximum bodyweights also yielded linear plots with a BME of 0.504 for all warm blooded species except primates which had a BME of 0.25. When lens volumes were compared with eye volumes, all species yielded a scaling constant of 0.75 but the proportionality constants for primates and birds were lower. CONCLUSIONS: Ontogenic lens growth is fastest, relative to body growth, in small animals and slowest in large animals. Fiber cell compaction takes place throughout life in most species, but not in birds and reptiles. Maximum adult lens size scales with eye size with the same exponent in all species, but birds and primates have smaller lenses relative to eye size than other species. Optical properties of the lens are generated through the combination of variations in the rate of growth, rate of compaction, shape and size. Molecular Vision 2014-03-30 /pmc/articles/PMC3976690/ /pubmed/24715759 Text en Copyright © 2014 Molecular Vision. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.
spellingShingle Research Article
Augusteyn, Robert C.
Growth of the eye lens: II. Allometric studies
title Growth of the eye lens: II. Allometric studies
title_full Growth of the eye lens: II. Allometric studies
title_fullStr Growth of the eye lens: II. Allometric studies
title_full_unstemmed Growth of the eye lens: II. Allometric studies
title_short Growth of the eye lens: II. Allometric studies
title_sort growth of the eye lens: ii. allometric studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976690/
https://www.ncbi.nlm.nih.gov/pubmed/24715759
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