Cargando…

Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation

Objective(s): Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohammadi-Samani, Soliman, Yousefi, Gholamhossein, Mohammadi, Farhad, Ahmadi, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976748/
https://www.ncbi.nlm.nih.gov/pubmed/24711894
_version_ 1782310321400053760
author Mohammadi-Samani, Soliman
Yousefi, Gholamhossein
Mohammadi, Farhad
Ahmadi, Fatemeh
author_facet Mohammadi-Samani, Soliman
Yousefi, Gholamhossein
Mohammadi, Farhad
Ahmadi, Fatemeh
author_sort Mohammadi-Samani, Soliman
collection PubMed
description Objective(s): Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no topical form in the market. In this research, we attempted to quantify the skin permeation of a meloxicam topical preparation and to show how permeation would be increased by using thymol as an enhancer. The effect of eutectic point of drug and thymol mixture on rate and extent of skin permeation was also studied. Materials and Methods: Different mixtures of thymol and meloxicam (2:8, 4:6, 5:5, 6:4, 8:2) were prepared and their melting point were obtained by differential scanning calorimetry. Then drug permeation was measured using diffusion cells and the Guinea pig skin. Results: Mixtures in ratios 5:5 and 4:6 of meloxicam / thymol showed a new endotherm at 149 and 140°C in DSC thermograms. The permeability of meloxicam from the creams containing 6:4, 5:5 and 4:6 ratios of meloxicam to thymol were 4.71, 15.2, 22.06 µg/cm(2) respectively. This was significantly different from the cream of pure meloxicam (3.76 µg/cm(2)). Conclusion: This study set out to determine that thymol plays as a skin permeation enhancer and increases the meloxicam skin absorption and this enhancement is significant at the eutectic point of drug-enhancer mixture.
format Online
Article
Text
id pubmed-3976748
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Mashhad University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-39767482014-04-07 Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation Mohammadi-Samani, Soliman Yousefi, Gholamhossein Mohammadi, Farhad Ahmadi, Fatemeh Iran J Basic Med Sci Original Article Objective(s): Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no topical form in the market. In this research, we attempted to quantify the skin permeation of a meloxicam topical preparation and to show how permeation would be increased by using thymol as an enhancer. The effect of eutectic point of drug and thymol mixture on rate and extent of skin permeation was also studied. Materials and Methods: Different mixtures of thymol and meloxicam (2:8, 4:6, 5:5, 6:4, 8:2) were prepared and their melting point were obtained by differential scanning calorimetry. Then drug permeation was measured using diffusion cells and the Guinea pig skin. Results: Mixtures in ratios 5:5 and 4:6 of meloxicam / thymol showed a new endotherm at 149 and 140°C in DSC thermograms. The permeability of meloxicam from the creams containing 6:4, 5:5 and 4:6 ratios of meloxicam to thymol were 4.71, 15.2, 22.06 µg/cm(2) respectively. This was significantly different from the cream of pure meloxicam (3.76 µg/cm(2)). Conclusion: This study set out to determine that thymol plays as a skin permeation enhancer and increases the meloxicam skin absorption and this enhancement is significant at the eutectic point of drug-enhancer mixture. Mashhad University of Medical Sciences 2014-02 /pmc/articles/PMC3976748/ /pubmed/24711894 Text en © 2014: Iranian Journal of Basic Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mohammadi-Samani, Soliman
Yousefi, Gholamhossein
Mohammadi, Farhad
Ahmadi, Fatemeh
Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation
title Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation
title_full Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation
title_fullStr Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation
title_full_unstemmed Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation
title_short Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation
title_sort meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976748/
https://www.ncbi.nlm.nih.gov/pubmed/24711894
work_keys_str_mv AT mohammadisamanisoliman meloxicamtransdermaldeliveryeffectofeutecticpointontherateandextentofskinpermeation
AT yousefigholamhossein meloxicamtransdermaldeliveryeffectofeutecticpointontherateandextentofskinpermeation
AT mohammadifarhad meloxicamtransdermaldeliveryeffectofeutecticpointontherateandextentofskinpermeation
AT ahmadifatemeh meloxicamtransdermaldeliveryeffectofeutecticpointontherateandextentofskinpermeation