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Hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition

Objective(s): Hyperglycemia worsens the neuronal death induced by cerebral ischemia. Previous studies demonstrated that diabetic hyperglycemia suppressed the expression of heat shock protein 70 and 60 (HSP70 and 60) in the liver. IgG antibody titres against heat shock protein 27 (anti HSP27) were me...

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Autores principales: Mousavi, Seyedeh Neda, Samini, Fariborz, Nematy, Mohsen, Philippou, Elena, Safarian, Mohammad, Tavallaiee, Shima, Norouzy, Abdolreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976749/
https://www.ncbi.nlm.nih.gov/pubmed/24711895
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author Mousavi, Seyedeh Neda
Samini, Fariborz
Nematy, Mohsen
Philippou, Elena
Safarian, Mohammad
Tavallaiee, Shima
Norouzy, Abdolreza
author_facet Mousavi, Seyedeh Neda
Samini, Fariborz
Nematy, Mohsen
Philippou, Elena
Safarian, Mohammad
Tavallaiee, Shima
Norouzy, Abdolreza
author_sort Mousavi, Seyedeh Neda
collection PubMed
description Objective(s): Hyperglycemia worsens the neuronal death induced by cerebral ischemia. Previous studies demonstrated that diabetic hyperglycemia suppressed the expression of heat shock protein 70 and 60 (HSP70 and 60) in the liver. IgG antibody titres against heat shock protein 27 (anti HSP27) were measured to determine whether hyperglycemia exacerbates ischemic brain damage by suppressing the expression of heat shock protein 27 (HSP27) in the brain. Materials and Methods: A randomized controlled study of traumatic brain injury ICU patients treated either by intensive insulin treatment (IIT) or by conventional glucose control (CGC) was conducted. Patients received at least 50% of their estimated daily energy requirements parenterally. Serum anti HSP27 antibody concentration was assessed at baseline, day 7 and day 14. Results: Twenty-six out of 29 patients (n=13 in each group) completed the study. At baseline, there were no differences between the two groups. On day 14, there was a significant reduction in anti HSP27 titre concentration in the IIT compared to the GCG group (0.47±0.27 mg/dl vs 0.60±0.15 mg/dl, P=0.03). Conclusion: In this study, intensive control of traumatic brain injury patients on parenteral nutrition reduced anti HSP27 titre, possibly suggesting a reduction in stress.
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spelling pubmed-39767492014-04-07 Hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition Mousavi, Seyedeh Neda Samini, Fariborz Nematy, Mohsen Philippou, Elena Safarian, Mohammad Tavallaiee, Shima Norouzy, Abdolreza Iran J Basic Med Sci Original Article Objective(s): Hyperglycemia worsens the neuronal death induced by cerebral ischemia. Previous studies demonstrated that diabetic hyperglycemia suppressed the expression of heat shock protein 70 and 60 (HSP70 and 60) in the liver. IgG antibody titres against heat shock protein 27 (anti HSP27) were measured to determine whether hyperglycemia exacerbates ischemic brain damage by suppressing the expression of heat shock protein 27 (HSP27) in the brain. Materials and Methods: A randomized controlled study of traumatic brain injury ICU patients treated either by intensive insulin treatment (IIT) or by conventional glucose control (CGC) was conducted. Patients received at least 50% of their estimated daily energy requirements parenterally. Serum anti HSP27 antibody concentration was assessed at baseline, day 7 and day 14. Results: Twenty-six out of 29 patients (n=13 in each group) completed the study. At baseline, there were no differences between the two groups. On day 14, there was a significant reduction in anti HSP27 titre concentration in the IIT compared to the GCG group (0.47±0.27 mg/dl vs 0.60±0.15 mg/dl, P=0.03). Conclusion: In this study, intensive control of traumatic brain injury patients on parenteral nutrition reduced anti HSP27 titre, possibly suggesting a reduction in stress. Mashhad University of Medical Sciences 2014-02 /pmc/articles/PMC3976749/ /pubmed/24711895 Text en © 2014: Iranian Journal of Basic Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mousavi, Seyedeh Neda
Samini, Fariborz
Nematy, Mohsen
Philippou, Elena
Safarian, Mohammad
Tavallaiee, Shima
Norouzy, Abdolreza
Hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition
title Hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition
title_full Hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition
title_fullStr Hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition
title_full_unstemmed Hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition
title_short Hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition
title_sort hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976749/
https://www.ncbi.nlm.nih.gov/pubmed/24711895
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