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Functional Outcomes and Quality of Life after Restorative Proctocolectomy in Paediatric Patients: A Case-Control Study

Background. Restorative proctocolectomy with ileal-pouch anal anastomosis (IPAA) has some peculiarities in paediatric ulcerative colitis (UC). Aims. The primary aim was to compare the bowel function of patients undergoing IPAA between those operated on in childhood and adulthood. The secondary aim w...

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Autores principales: Pellino, Gianluca, Sciaudone, Guido, Miele, Erasmo, Candilio, Giuseppe, De Fatico, Gilda Serena, Riegler, Gabriele, Staiano, Annamaria, Canonico, Silvestro, Selvaggi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976779/
https://www.ncbi.nlm.nih.gov/pubmed/24744776
http://dx.doi.org/10.1155/2014/340341
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author Pellino, Gianluca
Sciaudone, Guido
Miele, Erasmo
Candilio, Giuseppe
De Fatico, Gilda Serena
Riegler, Gabriele
Staiano, Annamaria
Canonico, Silvestro
Selvaggi, Francesco
author_facet Pellino, Gianluca
Sciaudone, Guido
Miele, Erasmo
Candilio, Giuseppe
De Fatico, Gilda Serena
Riegler, Gabriele
Staiano, Annamaria
Canonico, Silvestro
Selvaggi, Francesco
author_sort Pellino, Gianluca
collection PubMed
description Background. Restorative proctocolectomy with ileal-pouch anal anastomosis (IPAA) has some peculiarities in paediatric ulcerative colitis (UC). Aims. The primary aim was to compare the bowel function of patients undergoing IPAA between those operated on in childhood and adulthood. The secondary aim was to compare the quality of life (QoL) and outcomes for children between medical and surgical therapies. Method. Children undergoing IPAA were compared with adult patients undergoing IPAA between 2007 and 2012. Function was assessed 1 year after ileostomy closure. Function and QoL of medically managed paediatric patients were compared with their surgical counterparts. Results. Twelve paediatric IPAA patients were compared with 24 adult ones. Acute presentation was common in the former, usually after failed biological treatment. Recurrent pouchitis was more frequent in children. Younger patients exhibited a trend toward better discrimination and continence. QoL was excellent in both groups. Twelve medically treated children were enrolled for secondary aim. Functioning was similar in IPAA- and medically managed children, but the former had a better QoL, confirmed by parents' perception. Conclusions. Similar function is achieved by IPAA in childhood or adulthood. IPAA may offer a better QoL compared to prolonged medical management. The beneficial effects of IPAA experienced by children were similarly observed by their parents.
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spelling pubmed-39767792014-04-17 Functional Outcomes and Quality of Life after Restorative Proctocolectomy in Paediatric Patients: A Case-Control Study Pellino, Gianluca Sciaudone, Guido Miele, Erasmo Candilio, Giuseppe De Fatico, Gilda Serena Riegler, Gabriele Staiano, Annamaria Canonico, Silvestro Selvaggi, Francesco Gastroenterol Res Pract Clinical Study Background. Restorative proctocolectomy with ileal-pouch anal anastomosis (IPAA) has some peculiarities in paediatric ulcerative colitis (UC). Aims. The primary aim was to compare the bowel function of patients undergoing IPAA between those operated on in childhood and adulthood. The secondary aim was to compare the quality of life (QoL) and outcomes for children between medical and surgical therapies. Method. Children undergoing IPAA were compared with adult patients undergoing IPAA between 2007 and 2012. Function was assessed 1 year after ileostomy closure. Function and QoL of medically managed paediatric patients were compared with their surgical counterparts. Results. Twelve paediatric IPAA patients were compared with 24 adult ones. Acute presentation was common in the former, usually after failed biological treatment. Recurrent pouchitis was more frequent in children. Younger patients exhibited a trend toward better discrimination and continence. QoL was excellent in both groups. Twelve medically treated children were enrolled for secondary aim. Functioning was similar in IPAA- and medically managed children, but the former had a better QoL, confirmed by parents' perception. Conclusions. Similar function is achieved by IPAA in childhood or adulthood. IPAA may offer a better QoL compared to prolonged medical management. The beneficial effects of IPAA experienced by children were similarly observed by their parents. Hindawi Publishing Corporation 2014 2014-03-16 /pmc/articles/PMC3976779/ /pubmed/24744776 http://dx.doi.org/10.1155/2014/340341 Text en Copyright © 2014 Gianluca Pellino et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Pellino, Gianluca
Sciaudone, Guido
Miele, Erasmo
Candilio, Giuseppe
De Fatico, Gilda Serena
Riegler, Gabriele
Staiano, Annamaria
Canonico, Silvestro
Selvaggi, Francesco
Functional Outcomes and Quality of Life after Restorative Proctocolectomy in Paediatric Patients: A Case-Control Study
title Functional Outcomes and Quality of Life after Restorative Proctocolectomy in Paediatric Patients: A Case-Control Study
title_full Functional Outcomes and Quality of Life after Restorative Proctocolectomy in Paediatric Patients: A Case-Control Study
title_fullStr Functional Outcomes and Quality of Life after Restorative Proctocolectomy in Paediatric Patients: A Case-Control Study
title_full_unstemmed Functional Outcomes and Quality of Life after Restorative Proctocolectomy in Paediatric Patients: A Case-Control Study
title_short Functional Outcomes and Quality of Life after Restorative Proctocolectomy in Paediatric Patients: A Case-Control Study
title_sort functional outcomes and quality of life after restorative proctocolectomy in paediatric patients: a case-control study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976779/
https://www.ncbi.nlm.nih.gov/pubmed/24744776
http://dx.doi.org/10.1155/2014/340341
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