Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma

Long noncoding RNAs (lncRNAs) have been attracting immense research interests. However, only a handful of lncRNAs had been thoroughly characterized. They were involved in fundamental cellular processes including regulation of gene expression at epigenetics as well as tumorogenesis. In this paper, we...

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Autores principales: Li, Guangbing, Zhang, Haohai, Wan, Xueshuai, Yang, Xiaobo, Zhu, Chengpei, Wang, Anqiang, He, Lian, Miao, Ruoyu, Chen, Shuguang, Zhao, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976793/
https://www.ncbi.nlm.nih.gov/pubmed/24757675
http://dx.doi.org/10.1155/2014/780521
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author Li, Guangbing
Zhang, Haohai
Wan, Xueshuai
Yang, Xiaobo
Zhu, Chengpei
Wang, Anqiang
He, Lian
Miao, Ruoyu
Chen, Shuguang
Zhao, Haitao
author_facet Li, Guangbing
Zhang, Haohai
Wan, Xueshuai
Yang, Xiaobo
Zhu, Chengpei
Wang, Anqiang
He, Lian
Miao, Ruoyu
Chen, Shuguang
Zhao, Haitao
author_sort Li, Guangbing
collection PubMed
description Long noncoding RNAs (lncRNAs) have been attracting immense research interests. However, only a handful of lncRNAs had been thoroughly characterized. They were involved in fundamental cellular processes including regulation of gene expression at epigenetics as well as tumorogenesis. In this paper, we give a systematic and comprehensive review of existing literature about lncRNA involvement in hepatocellular carcinoma. This review exhibited that lncRNAs played important roles in tumorigenesis and subsequent prognosis and metastasis of hepatocellular carcinoma and elucidated the role of some specific lncRNAs such as MALAT1 and HOTAIR in the pathophysiology of hepatocellular carcinoma and their potential of being therapeutic targets.
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spelling pubmed-39767932014-04-22 Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma Li, Guangbing Zhang, Haohai Wan, Xueshuai Yang, Xiaobo Zhu, Chengpei Wang, Anqiang He, Lian Miao, Ruoyu Chen, Shuguang Zhao, Haitao Biomed Res Int Review Article Long noncoding RNAs (lncRNAs) have been attracting immense research interests. However, only a handful of lncRNAs had been thoroughly characterized. They were involved in fundamental cellular processes including regulation of gene expression at epigenetics as well as tumorogenesis. In this paper, we give a systematic and comprehensive review of existing literature about lncRNA involvement in hepatocellular carcinoma. This review exhibited that lncRNAs played important roles in tumorigenesis and subsequent prognosis and metastasis of hepatocellular carcinoma and elucidated the role of some specific lncRNAs such as MALAT1 and HOTAIR in the pathophysiology of hepatocellular carcinoma and their potential of being therapeutic targets. Hindawi Publishing Corporation 2014 2014-03-16 /pmc/articles/PMC3976793/ /pubmed/24757675 http://dx.doi.org/10.1155/2014/780521 Text en Copyright © 2014 Guangbing Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Guangbing
Zhang, Haohai
Wan, Xueshuai
Yang, Xiaobo
Zhu, Chengpei
Wang, Anqiang
He, Lian
Miao, Ruoyu
Chen, Shuguang
Zhao, Haitao
Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma
title Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma
title_full Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma
title_fullStr Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma
title_full_unstemmed Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma
title_short Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma
title_sort long noncoding rna plays a key role in metastasis and prognosis of hepatocellular carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976793/
https://www.ncbi.nlm.nih.gov/pubmed/24757675
http://dx.doi.org/10.1155/2014/780521
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