The Role of Suppressors of Cytokine Signalling in Human Neoplasms

Suppressors of cytokine signalling 1–7 (SOCS1–7) and cytokine-inducible SH2-containing protein (CIS) are a group of intracellular proteins that are well known as JAK-STAT and several other signalling pathways negative feedback regulators. More recently several members have been identified as tumour...

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Detalles Bibliográficos
Autores principales: Sasi, Walid, Sharma, Anup K., Mokbel, Kefah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976820/
https://www.ncbi.nlm.nih.gov/pubmed/24757565
http://dx.doi.org/10.1155/2014/630797
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author Sasi, Walid
Sharma, Anup K.
Mokbel, Kefah
author_facet Sasi, Walid
Sharma, Anup K.
Mokbel, Kefah
author_sort Sasi, Walid
collection PubMed
description Suppressors of cytokine signalling 1–7 (SOCS1–7) and cytokine-inducible SH2-containing protein (CIS) are a group of intracellular proteins that are well known as JAK-STAT and several other signalling pathways negative feedback regulators. More recently several members have been identified as tumour suppressors and dysregulation of their biological roles in controlling cytokine and growth factor signalling may contribute to the development of many solid organ and haematological malignancies. This review explores their biological functions and their possible tumour suppressing role in human neoplasms.
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spelling pubmed-39768202014-04-22 The Role of Suppressors of Cytokine Signalling in Human Neoplasms Sasi, Walid Sharma, Anup K. Mokbel, Kefah Mol Biol Int Review Article Suppressors of cytokine signalling 1–7 (SOCS1–7) and cytokine-inducible SH2-containing protein (CIS) are a group of intracellular proteins that are well known as JAK-STAT and several other signalling pathways negative feedback regulators. More recently several members have been identified as tumour suppressors and dysregulation of their biological roles in controlling cytokine and growth factor signalling may contribute to the development of many solid organ and haematological malignancies. This review explores their biological functions and their possible tumour suppressing role in human neoplasms. Hindawi Publishing Corporation 2014 2014-03-16 /pmc/articles/PMC3976820/ /pubmed/24757565 http://dx.doi.org/10.1155/2014/630797 Text en Copyright © 2014 Walid Sasi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sasi, Walid
Sharma, Anup K.
Mokbel, Kefah
The Role of Suppressors of Cytokine Signalling in Human Neoplasms
title The Role of Suppressors of Cytokine Signalling in Human Neoplasms
title_full The Role of Suppressors of Cytokine Signalling in Human Neoplasms
title_fullStr The Role of Suppressors of Cytokine Signalling in Human Neoplasms
title_full_unstemmed The Role of Suppressors of Cytokine Signalling in Human Neoplasms
title_short The Role of Suppressors of Cytokine Signalling in Human Neoplasms
title_sort role of suppressors of cytokine signalling in human neoplasms
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976820/
https://www.ncbi.nlm.nih.gov/pubmed/24757565
http://dx.doi.org/10.1155/2014/630797
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