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Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population
Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD). The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channel...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976823/ https://www.ncbi.nlm.nih.gov/pubmed/24745010 http://dx.doi.org/10.1155/2014/290863 |
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author | Hwang, Daw-Yang Chien, Shu-Chen Hsu, Yu-Wen Kao, Chih-Chin Cheng, Shih-Ying Lu, Hui-Chen Wu, Mai-Szu Chang, Jer-Ming |
author_facet | Hwang, Daw-Yang Chien, Shu-Chen Hsu, Yu-Wen Kao, Chih-Chin Cheng, Shih-Ying Lu, Hui-Chen Wu, Mai-Szu Chang, Jer-Ming |
author_sort | Hwang, Daw-Yang |
collection | PubMed |
description | Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD). The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involved in the regulation of immune system. Hence, we conducted a case-control study to determine whether the genetic polymorphisms of ORAI1 gene is a susceptibility factor to CKD and its clinical features in a Taiwanese population. Five hundred seventy-nine CKD patients from a hospital-based CKD care program were included in the study. Five tagging single nucleotide polymorphisms (tSNPs) of ORAI1 were selected from the genotyping data of the Han Chinese population from the HapMap project. Among these polymorphisms, rs12313273 was found to be significantly associated with elevated serum calcium levels, which has been linked to increased risk of death in CKD patients. To have a better management of serum calcium, we suggest that ORAI1 polymorphisms might be used as a potential biomarker for initiating non-calcium-based phosphate binder in CKD patients in the future. |
format | Online Article Text |
id | pubmed-3976823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39768232014-04-17 Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population Hwang, Daw-Yang Chien, Shu-Chen Hsu, Yu-Wen Kao, Chih-Chin Cheng, Shih-Ying Lu, Hui-Chen Wu, Mai-Szu Chang, Jer-Ming Biomed Res Int Research Article Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD). The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involved in the regulation of immune system. Hence, we conducted a case-control study to determine whether the genetic polymorphisms of ORAI1 gene is a susceptibility factor to CKD and its clinical features in a Taiwanese population. Five hundred seventy-nine CKD patients from a hospital-based CKD care program were included in the study. Five tagging single nucleotide polymorphisms (tSNPs) of ORAI1 were selected from the genotyping data of the Han Chinese population from the HapMap project. Among these polymorphisms, rs12313273 was found to be significantly associated with elevated serum calcium levels, which has been linked to increased risk of death in CKD patients. To have a better management of serum calcium, we suggest that ORAI1 polymorphisms might be used as a potential biomarker for initiating non-calcium-based phosphate binder in CKD patients in the future. Hindawi Publishing Corporation 2014 2014-03-17 /pmc/articles/PMC3976823/ /pubmed/24745010 http://dx.doi.org/10.1155/2014/290863 Text en Copyright © 2014 Daw-Yang Hwang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hwang, Daw-Yang Chien, Shu-Chen Hsu, Yu-Wen Kao, Chih-Chin Cheng, Shih-Ying Lu, Hui-Chen Wu, Mai-Szu Chang, Jer-Ming Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population |
title | Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population |
title_full | Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population |
title_fullStr | Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population |
title_full_unstemmed | Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population |
title_short | Genetic Polymorphisms of ORAI1 and Chronic Kidney Disease in Taiwanese Population |
title_sort | genetic polymorphisms of orai1 and chronic kidney disease in taiwanese population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976823/ https://www.ncbi.nlm.nih.gov/pubmed/24745010 http://dx.doi.org/10.1155/2014/290863 |
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