Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm

Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by hyperproliferation of hematologic cell lines and have been associated with tyrosine kinase JAK2-V617F mutations. Secondary acute myeloid leukemia (sAML) is a known complication of JAK2-V617F+ MPNs and bears a poor p...

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Autores principales: Woods, Gary M., Bajwa, Rajinder P. S., Kahwash, Samir B., Guinipero, Terri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976921/
https://www.ncbi.nlm.nih.gov/pubmed/24744787
http://dx.doi.org/10.1155/2014/473297
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author Woods, Gary M.
Bajwa, Rajinder P. S.
Kahwash, Samir B.
Guinipero, Terri
author_facet Woods, Gary M.
Bajwa, Rajinder P. S.
Kahwash, Samir B.
Guinipero, Terri
author_sort Woods, Gary M.
collection PubMed
description Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by hyperproliferation of hematologic cell lines and have been associated with tyrosine kinase JAK2-V617F mutations. Secondary acute myeloid leukemia (sAML) is a known complication of JAK2-V617F+ MPNs and bears a poor prognosis. Although the evolution of a JAK2-V617F+ MPN to a mixed-lineage leukemia has been reported in the pediatric population, no evolutions into sAML have been described. We present a case of a one-year-old girl diagnosed with JAK2-V617F+ MPN with evolution into sAML. Despite initial morphologic remission, she eventually relapsed and succumbed to her disease.
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spelling pubmed-39769212014-04-17 Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm Woods, Gary M. Bajwa, Rajinder P. S. Kahwash, Samir B. Guinipero, Terri Case Rep Med Case Report Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by hyperproliferation of hematologic cell lines and have been associated with tyrosine kinase JAK2-V617F mutations. Secondary acute myeloid leukemia (sAML) is a known complication of JAK2-V617F+ MPNs and bears a poor prognosis. Although the evolution of a JAK2-V617F+ MPN to a mixed-lineage leukemia has been reported in the pediatric population, no evolutions into sAML have been described. We present a case of a one-year-old girl diagnosed with JAK2-V617F+ MPN with evolution into sAML. Despite initial morphologic remission, she eventually relapsed and succumbed to her disease. Hindawi Publishing Corporation 2014 2014-03-18 /pmc/articles/PMC3976921/ /pubmed/24744787 http://dx.doi.org/10.1155/2014/473297 Text en Copyright © 2014 Gary M. Woods et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Woods, Gary M.
Bajwa, Rajinder P. S.
Kahwash, Samir B.
Guinipero, Terri
Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm
title Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm
title_full Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm
title_fullStr Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm
title_full_unstemmed Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm
title_short Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm
title_sort secondary acute myeloid leukemia in a one-year-old girl diagnosed with jak2-v617f mutation positive myeloproliferative neoplasm
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976921/
https://www.ncbi.nlm.nih.gov/pubmed/24744787
http://dx.doi.org/10.1155/2014/473297
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