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Gender and Ocular Manifestations of Connective Tissue Diseases and Systemic Vasculitides

Ocular manifestations are present in many connective tissue diseases which are characterized by an immune system that is directed against self. In this paper, we review the ocular findings in various connective tissue diseases and systemic vasculitides and highlight gender differences in each diseas...

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Autores principales: Choudhary, Maria M., Hajj-Ali, Rula A., Lowder, Careen Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976932/
https://www.ncbi.nlm.nih.gov/pubmed/24757559
http://dx.doi.org/10.1155/2014/403042
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author Choudhary, Maria M.
Hajj-Ali, Rula A.
Lowder, Careen Y.
author_facet Choudhary, Maria M.
Hajj-Ali, Rula A.
Lowder, Careen Y.
author_sort Choudhary, Maria M.
collection PubMed
description Ocular manifestations are present in many connective tissue diseases which are characterized by an immune system that is directed against self. In this paper, we review the ocular findings in various connective tissue diseases and systemic vasculitides and highlight gender differences in each disease. In rheumatoid arthritis, we find that dry eyes affect women nine times more than men. The other extra-articular manifestations of rheumatoid arthritis affect women three times more commonly than men. Systemic lupus erythematosus can involve all ocular structures and women are nine times more affected than men. Systemic sclerosis is a rare disease but, again, it is more common in women with a female to male ratio of 8 : 1. Polymyositis and dermatomyositis also affect women more commonly than men but no gender differences have been found in the incidence or disease course in the systemic vasculitides associated with antineutrophil cytoplasmic antibody such as granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis). Finally, Behcet's disease is more common in males, and male gender is a risk factor for Behcet's disease. There is a slight female preponderance in sarcoidosis with female gender carrying a worse prognosis in the outcome of ocular disease.
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spelling pubmed-39769322014-04-22 Gender and Ocular Manifestations of Connective Tissue Diseases and Systemic Vasculitides Choudhary, Maria M. Hajj-Ali, Rula A. Lowder, Careen Y. J Ophthalmol Review Article Ocular manifestations are present in many connective tissue diseases which are characterized by an immune system that is directed against self. In this paper, we review the ocular findings in various connective tissue diseases and systemic vasculitides and highlight gender differences in each disease. In rheumatoid arthritis, we find that dry eyes affect women nine times more than men. The other extra-articular manifestations of rheumatoid arthritis affect women three times more commonly than men. Systemic lupus erythematosus can involve all ocular structures and women are nine times more affected than men. Systemic sclerosis is a rare disease but, again, it is more common in women with a female to male ratio of 8 : 1. Polymyositis and dermatomyositis also affect women more commonly than men but no gender differences have been found in the incidence or disease course in the systemic vasculitides associated with antineutrophil cytoplasmic antibody such as granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis). Finally, Behcet's disease is more common in males, and male gender is a risk factor for Behcet's disease. There is a slight female preponderance in sarcoidosis with female gender carrying a worse prognosis in the outcome of ocular disease. Hindawi Publishing Corporation 2014 2014-03-17 /pmc/articles/PMC3976932/ /pubmed/24757559 http://dx.doi.org/10.1155/2014/403042 Text en Copyright © 2014 Maria M. Choudhary et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Choudhary, Maria M.
Hajj-Ali, Rula A.
Lowder, Careen Y.
Gender and Ocular Manifestations of Connective Tissue Diseases and Systemic Vasculitides
title Gender and Ocular Manifestations of Connective Tissue Diseases and Systemic Vasculitides
title_full Gender and Ocular Manifestations of Connective Tissue Diseases and Systemic Vasculitides
title_fullStr Gender and Ocular Manifestations of Connective Tissue Diseases and Systemic Vasculitides
title_full_unstemmed Gender and Ocular Manifestations of Connective Tissue Diseases and Systemic Vasculitides
title_short Gender and Ocular Manifestations of Connective Tissue Diseases and Systemic Vasculitides
title_sort gender and ocular manifestations of connective tissue diseases and systemic vasculitides
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976932/
https://www.ncbi.nlm.nih.gov/pubmed/24757559
http://dx.doi.org/10.1155/2014/403042
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