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Quality of Life and Sexual Health in the Aging of PCa Survivors
Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976934/ https://www.ncbi.nlm.nih.gov/pubmed/24744780 http://dx.doi.org/10.1155/2014/470592 |
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author | Gacci, Mauro Baldi, Elisabetta Tamburrino, Lara Detti, Beatrice Livi, Lorenzo De Nunzio, Cosimo Tubaro, Andrea Gravas, Stavros Carini, Marco Serni, Sergio |
author_facet | Gacci, Mauro Baldi, Elisabetta Tamburrino, Lara Detti, Beatrice Livi, Lorenzo De Nunzio, Cosimo Tubaro, Andrea Gravas, Stavros Carini, Marco Serni, Sergio |
author_sort | Gacci, Mauro |
collection | PubMed |
description | Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. However, several trials on androgens and PCa are recently focused on urinary continence, quality of life, and sexual function, suggesting a new point of view on the whole endocrinological aspect of PCa. During aging, metabolic syndrome, including diabetes, hypertension, dyslipidemia, and central obesity, can be associated with a chronic, low-grade inflammation of the prostate and with changes in the sex steroid pathways. These factors may affect both the carcinogenesis processes and treatment outcomes of PCa. Any treatment for PCa can have a long-lasting negative impact on quality of life and sexual health, which should be assessed by validated self-reported questionnaires. In particular, sexual health, urinary continence, and bowel function can be worsened after prostatectomy, radiotherapy, or hormone treatment, mostly in the elderly population. In the present review we summarized the current knowledge on the role of hormones, metabolic features, and primary treatments for PCa on the quality of life and sexual health of elderly Pca survivors. |
format | Online Article Text |
id | pubmed-3976934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39769342014-04-17 Quality of Life and Sexual Health in the Aging of PCa Survivors Gacci, Mauro Baldi, Elisabetta Tamburrino, Lara Detti, Beatrice Livi, Lorenzo De Nunzio, Cosimo Tubaro, Andrea Gravas, Stavros Carini, Marco Serni, Sergio Int J Endocrinol Review Article Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. However, several trials on androgens and PCa are recently focused on urinary continence, quality of life, and sexual function, suggesting a new point of view on the whole endocrinological aspect of PCa. During aging, metabolic syndrome, including diabetes, hypertension, dyslipidemia, and central obesity, can be associated with a chronic, low-grade inflammation of the prostate and with changes in the sex steroid pathways. These factors may affect both the carcinogenesis processes and treatment outcomes of PCa. Any treatment for PCa can have a long-lasting negative impact on quality of life and sexual health, which should be assessed by validated self-reported questionnaires. In particular, sexual health, urinary continence, and bowel function can be worsened after prostatectomy, radiotherapy, or hormone treatment, mostly in the elderly population. In the present review we summarized the current knowledge on the role of hormones, metabolic features, and primary treatments for PCa on the quality of life and sexual health of elderly Pca survivors. Hindawi Publishing Corporation 2014 2014-03-17 /pmc/articles/PMC3976934/ /pubmed/24744780 http://dx.doi.org/10.1155/2014/470592 Text en Copyright © 2014 Mauro Gacci et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gacci, Mauro Baldi, Elisabetta Tamburrino, Lara Detti, Beatrice Livi, Lorenzo De Nunzio, Cosimo Tubaro, Andrea Gravas, Stavros Carini, Marco Serni, Sergio Quality of Life and Sexual Health in the Aging of PCa Survivors |
title | Quality of Life and Sexual Health in the Aging of PCa Survivors |
title_full | Quality of Life and Sexual Health in the Aging of PCa Survivors |
title_fullStr | Quality of Life and Sexual Health in the Aging of PCa Survivors |
title_full_unstemmed | Quality of Life and Sexual Health in the Aging of PCa Survivors |
title_short | Quality of Life and Sexual Health in the Aging of PCa Survivors |
title_sort | quality of life and sexual health in the aging of pca survivors |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976934/ https://www.ncbi.nlm.nih.gov/pubmed/24744780 http://dx.doi.org/10.1155/2014/470592 |
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