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Quality of Life and Sexual Health in the Aging of PCa Survivors

Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been...

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Autores principales: Gacci, Mauro, Baldi, Elisabetta, Tamburrino, Lara, Detti, Beatrice, Livi, Lorenzo, De Nunzio, Cosimo, Tubaro, Andrea, Gravas, Stavros, Carini, Marco, Serni, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976934/
https://www.ncbi.nlm.nih.gov/pubmed/24744780
http://dx.doi.org/10.1155/2014/470592
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author Gacci, Mauro
Baldi, Elisabetta
Tamburrino, Lara
Detti, Beatrice
Livi, Lorenzo
De Nunzio, Cosimo
Tubaro, Andrea
Gravas, Stavros
Carini, Marco
Serni, Sergio
author_facet Gacci, Mauro
Baldi, Elisabetta
Tamburrino, Lara
Detti, Beatrice
Livi, Lorenzo
De Nunzio, Cosimo
Tubaro, Andrea
Gravas, Stavros
Carini, Marco
Serni, Sergio
author_sort Gacci, Mauro
collection PubMed
description Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. However, several trials on androgens and PCa are recently focused on urinary continence, quality of life, and sexual function, suggesting a new point of view on the whole endocrinological aspect of PCa. During aging, metabolic syndrome, including diabetes, hypertension, dyslipidemia, and central obesity, can be associated with a chronic, low-grade inflammation of the prostate and with changes in the sex steroid pathways. These factors may affect both the carcinogenesis processes and treatment outcomes of PCa. Any treatment for PCa can have a long-lasting negative impact on quality of life and sexual health, which should be assessed by validated self-reported questionnaires. In particular, sexual health, urinary continence, and bowel function can be worsened after prostatectomy, radiotherapy, or hormone treatment, mostly in the elderly population. In the present review we summarized the current knowledge on the role of hormones, metabolic features, and primary treatments for PCa on the quality of life and sexual health of elderly Pca survivors.
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spelling pubmed-39769342014-04-17 Quality of Life and Sexual Health in the Aging of PCa Survivors Gacci, Mauro Baldi, Elisabetta Tamburrino, Lara Detti, Beatrice Livi, Lorenzo De Nunzio, Cosimo Tubaro, Andrea Gravas, Stavros Carini, Marco Serni, Sergio Int J Endocrinol Review Article Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. However, several trials on androgens and PCa are recently focused on urinary continence, quality of life, and sexual function, suggesting a new point of view on the whole endocrinological aspect of PCa. During aging, metabolic syndrome, including diabetes, hypertension, dyslipidemia, and central obesity, can be associated with a chronic, low-grade inflammation of the prostate and with changes in the sex steroid pathways. These factors may affect both the carcinogenesis processes and treatment outcomes of PCa. Any treatment for PCa can have a long-lasting negative impact on quality of life and sexual health, which should be assessed by validated self-reported questionnaires. In particular, sexual health, urinary continence, and bowel function can be worsened after prostatectomy, radiotherapy, or hormone treatment, mostly in the elderly population. In the present review we summarized the current knowledge on the role of hormones, metabolic features, and primary treatments for PCa on the quality of life and sexual health of elderly Pca survivors. Hindawi Publishing Corporation 2014 2014-03-17 /pmc/articles/PMC3976934/ /pubmed/24744780 http://dx.doi.org/10.1155/2014/470592 Text en Copyright © 2014 Mauro Gacci et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gacci, Mauro
Baldi, Elisabetta
Tamburrino, Lara
Detti, Beatrice
Livi, Lorenzo
De Nunzio, Cosimo
Tubaro, Andrea
Gravas, Stavros
Carini, Marco
Serni, Sergio
Quality of Life and Sexual Health in the Aging of PCa Survivors
title Quality of Life and Sexual Health in the Aging of PCa Survivors
title_full Quality of Life and Sexual Health in the Aging of PCa Survivors
title_fullStr Quality of Life and Sexual Health in the Aging of PCa Survivors
title_full_unstemmed Quality of Life and Sexual Health in the Aging of PCa Survivors
title_short Quality of Life and Sexual Health in the Aging of PCa Survivors
title_sort quality of life and sexual health in the aging of pca survivors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976934/
https://www.ncbi.nlm.nih.gov/pubmed/24744780
http://dx.doi.org/10.1155/2014/470592
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