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Contribution of GTPase activity to LRRK2-associated Parkinson disease

Mutations in the leucine-rich repeat kinase 2 (LRRK2, PARK8, OMIM 607060) gene represent the most common known cause of hereditary Parkinson’s disease (PD) with late-onset and dominant inheritance. LRRK2 protein is composed of multiple domains including two distinct enzymatic domains, a kinase and a...

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Detalles Bibliográficos
Autores principales: Tsika, Elpida, Moore, Darren J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976973/
https://www.ncbi.nlm.nih.gov/pubmed/24025585
http://dx.doi.org/10.4161/sgtp.25130