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Treatment outcome of ductal carcinoma in situ patients treated with postoperative radiation therapy
PURPOSE: To evaluate the outcome of ductal carcinoma in situ (DCIS) patients who underwent surgery followed by radiation therapy (RT). MATERIALS AND METHODS: We retrospectively reviewed 106 DCIS patients who underwent surgery followed by postoperative RT between 1994 and 2006. Ninety-four patients u...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Radiation Oncology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977126/ https://www.ncbi.nlm.nih.gov/pubmed/24724045 http://dx.doi.org/10.3857/roj.2014.32.1.1 |
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author | Lim, Yu Jin Kim, Kyubo Chie, Eui Kyu Han, Wonshik Noh, Dong Young Ha, Sung W. |
author_facet | Lim, Yu Jin Kim, Kyubo Chie, Eui Kyu Han, Wonshik Noh, Dong Young Ha, Sung W. |
author_sort | Lim, Yu Jin |
collection | PubMed |
description | PURPOSE: To evaluate the outcome of ductal carcinoma in situ (DCIS) patients who underwent surgery followed by radiation therapy (RT). MATERIALS AND METHODS: We retrospectively reviewed 106 DCIS patients who underwent surgery followed by postoperative RT between 1994 and 2006. Ninety-four patients underwent breast-conserving surgery, and mastectomy was performed in 12 patients due to extensive DCIS. Postoperative RT was delivered to whole breast with 50.4 Gy/28 fx. Tumor bed boost was offered to 7 patients (6.6%). Patients with hormonal receptor-positive tumors were treated with hormonal therapy. RESULTS: The median follow-up duration was 83.4 months (range, 33.4 to 191.5 months) and the median age was 47.8 years. Ten patients (9.4%) had resection margin <1 mm and high-grade and estrogen receptor-negative tumors were observed in 39 (36.8%) and 20 (18.9%) patients, respectively. The 7-year ipsilateral breast tumor recurrence (IBTR)-free survival rate was 95.3%. Resection margin (<1 or ≥1 mm) was the significant prognostic factor for IBTR in univariate and multivariate analyses (p < 0.001 and p = 0.016, respectively). CONCLUSION: Postoperative RT for DCIS can achieve favorable treatment outcome. Resection margin was the important prognostic factor for IBTR in the DCIS patients who underwent postoperative RT. |
format | Online Article Text |
id | pubmed-3977126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Society for Radiation Oncology |
record_format | MEDLINE/PubMed |
spelling | pubmed-39771262014-04-10 Treatment outcome of ductal carcinoma in situ patients treated with postoperative radiation therapy Lim, Yu Jin Kim, Kyubo Chie, Eui Kyu Han, Wonshik Noh, Dong Young Ha, Sung W. Radiat Oncol J Original Article PURPOSE: To evaluate the outcome of ductal carcinoma in situ (DCIS) patients who underwent surgery followed by radiation therapy (RT). MATERIALS AND METHODS: We retrospectively reviewed 106 DCIS patients who underwent surgery followed by postoperative RT between 1994 and 2006. Ninety-four patients underwent breast-conserving surgery, and mastectomy was performed in 12 patients due to extensive DCIS. Postoperative RT was delivered to whole breast with 50.4 Gy/28 fx. Tumor bed boost was offered to 7 patients (6.6%). Patients with hormonal receptor-positive tumors were treated with hormonal therapy. RESULTS: The median follow-up duration was 83.4 months (range, 33.4 to 191.5 months) and the median age was 47.8 years. Ten patients (9.4%) had resection margin <1 mm and high-grade and estrogen receptor-negative tumors were observed in 39 (36.8%) and 20 (18.9%) patients, respectively. The 7-year ipsilateral breast tumor recurrence (IBTR)-free survival rate was 95.3%. Resection margin (<1 or ≥1 mm) was the significant prognostic factor for IBTR in univariate and multivariate analyses (p < 0.001 and p = 0.016, respectively). CONCLUSION: Postoperative RT for DCIS can achieve favorable treatment outcome. Resection margin was the important prognostic factor for IBTR in the DCIS patients who underwent postoperative RT. The Korean Society for Radiation Oncology 2014-03 2014-03-27 /pmc/articles/PMC3977126/ /pubmed/24724045 http://dx.doi.org/10.3857/roj.2014.32.1.1 Text en Copyright © 2014. The Korean Society for Radiation Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lim, Yu Jin Kim, Kyubo Chie, Eui Kyu Han, Wonshik Noh, Dong Young Ha, Sung W. Treatment outcome of ductal carcinoma in situ patients treated with postoperative radiation therapy |
title | Treatment outcome of ductal carcinoma in situ patients treated with postoperative radiation therapy |
title_full | Treatment outcome of ductal carcinoma in situ patients treated with postoperative radiation therapy |
title_fullStr | Treatment outcome of ductal carcinoma in situ patients treated with postoperative radiation therapy |
title_full_unstemmed | Treatment outcome of ductal carcinoma in situ patients treated with postoperative radiation therapy |
title_short | Treatment outcome of ductal carcinoma in situ patients treated with postoperative radiation therapy |
title_sort | treatment outcome of ductal carcinoma in situ patients treated with postoperative radiation therapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977126/ https://www.ncbi.nlm.nih.gov/pubmed/24724045 http://dx.doi.org/10.3857/roj.2014.32.1.1 |
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