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Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies

The relationship between thrombopoietin (TPO) and its receptor cMpl in thrombocytopenic conditions has not been entirely clarified. To elucidate this interplay may expand the spectrum of indications of TPO mimetics. In this study we have explored the relationship between TPO and cMpl in platelets an...

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Autores principales: Vianello, Fabrizio, Vettore, Silvia, Tezza, Fabiana, Toni, Luca De, Scandellari, Raffaella, Sambado, Luisa, Treleani, Martina, Fabris, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977153/
https://www.ncbi.nlm.nih.gov/pubmed/24711916
http://dx.doi.org/10.4081/hr.2014.4996
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author Vianello, Fabrizio
Vettore, Silvia
Tezza, Fabiana
Toni, Luca De
Scandellari, Raffaella
Sambado, Luisa
Treleani, Martina
Fabris, Fabrizio
author_facet Vianello, Fabrizio
Vettore, Silvia
Tezza, Fabiana
Toni, Luca De
Scandellari, Raffaella
Sambado, Luisa
Treleani, Martina
Fabris, Fabrizio
author_sort Vianello, Fabrizio
collection PubMed
description The relationship between thrombopoietin (TPO) and its receptor cMpl in thrombocytopenic conditions has not been entirely clarified. To elucidate this interplay may expand the spectrum of indications of TPO mimetics. In this study we have explored the relationship between TPO and cMpl in platelets and megakaryocytes of 43 patients with thrombocytopenia due to idiopathic thrombocytopenic purpura (ITP), bone marrow hypoplasia, myelodysplastic syndromes (MDS), and familial thrombocytopenia. Data were compared to cMpl and TPO in patients with a normal platelet count and in patients with thrombocytosis due to essential thrombocythemia (ET). All but familial patients showed higher TPO compared to controls. All thrombocytopenic states were invariably associated with increased expression of platelet cMPL compared to healthy controls. ET patients showed normal TPO and a trend toward a reduced cMpl expression. Immunofluorescence of bone marrow sections from patients with ITP and MDS failed to show a peculiar pattern compared to controls. Multiple mechanisms regulate TPO and cMpl in thrombocytopenic conditions.
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spelling pubmed-39771532014-04-07 Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies Vianello, Fabrizio Vettore, Silvia Tezza, Fabiana Toni, Luca De Scandellari, Raffaella Sambado, Luisa Treleani, Martina Fabris, Fabrizio Hematol Rep Article The relationship between thrombopoietin (TPO) and its receptor cMpl in thrombocytopenic conditions has not been entirely clarified. To elucidate this interplay may expand the spectrum of indications of TPO mimetics. In this study we have explored the relationship between TPO and cMpl in platelets and megakaryocytes of 43 patients with thrombocytopenia due to idiopathic thrombocytopenic purpura (ITP), bone marrow hypoplasia, myelodysplastic syndromes (MDS), and familial thrombocytopenia. Data were compared to cMpl and TPO in patients with a normal platelet count and in patients with thrombocytosis due to essential thrombocythemia (ET). All but familial patients showed higher TPO compared to controls. All thrombocytopenic states were invariably associated with increased expression of platelet cMPL compared to healthy controls. ET patients showed normal TPO and a trend toward a reduced cMpl expression. Immunofluorescence of bone marrow sections from patients with ITP and MDS failed to show a peculiar pattern compared to controls. Multiple mechanisms regulate TPO and cMpl in thrombocytopenic conditions. PAGEPress Publications, Pavia, Italy 2014-03-26 /pmc/articles/PMC3977153/ /pubmed/24711916 http://dx.doi.org/10.4081/hr.2014.4996 Text en ©Copyright F. Vianello et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Vianello, Fabrizio
Vettore, Silvia
Tezza, Fabiana
Toni, Luca De
Scandellari, Raffaella
Sambado, Luisa
Treleani, Martina
Fabris, Fabrizio
Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies
title Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies
title_full Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies
title_fullStr Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies
title_full_unstemmed Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies
title_short Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies
title_sort serum thrombopoietin and cmpl expression in thrombocytopenia of different etiologies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977153/
https://www.ncbi.nlm.nih.gov/pubmed/24711916
http://dx.doi.org/10.4081/hr.2014.4996
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