A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant

Cross-species transmission of zoonotic coronaviruses (CoVs) can result in pandemic disease outbreaks. Middle East respiratory syndrome CoV (MERS-CoV), identified in 2012, has caused 182 cases to date, with ~43% mortality, and no small animal model has been reported. MERS-CoV and Pipistrellus bat cor...

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Detalles Bibliográficos
Autores principales: Agnihothram, Sudhakar, Yount, Boyd L., Donaldson, Eric F., Huynh, Jeremy, Menachery, Vineet D., Gralinski, Lisa E., Graham, Rachel L., Becker, Michelle M., Tomar, Sakshi, Scobey, Trevor D., Osswald, Heather L., Whitmore, Alan, Gopal, Robin, Ghosh, Arun K., Mesecar, Andrew, Zambon, Maria, Heise, Mark, Denison, Mark R., Baric, Ralph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977350/
https://www.ncbi.nlm.nih.gov/pubmed/24667706
http://dx.doi.org/10.1128/mBio.00047-14

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