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Complex RNA Folding Kinetics Revealed by Single-Molecule FRET and Hidden Markov Models

[Image: see text] We have developed a hidden Markov model and optimization procedure for photon-based single-molecule FRET data, which takes into account the trace-dependent background intensities. This analysis technique reveals an unprecedented amount of detail in the folding kinetics of the Diels...

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Detalles Bibliográficos
Autores principales:	Keller, Bettina G., Kobitski, Andrei, Jäschke, Andres, Nienhaus, G. Ulrich, Noé, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977575/ https://www.ncbi.nlm.nih.gov/pubmed/24568646 http://dx.doi.org/10.1021/ja4098719

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