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Probing Kinase Activation and Substrate Specificity with an Engineered Monomeric IKK2

[Image: see text] Catalytic subunits of the IκB kinase (IKK), IKK1/IKKα, and IKK2/IKKβ function in vivo as dimers in association with the necessary scaffolding subunit NEMO/IKKγ. Recent X-ray crystal structures of IKK2 suggested that dimerization might be mediated by a smaller protein–protein intera...

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Detalles Bibliográficos
Autores principales:	Hauenstein, Arthur V., Rogers, W. Eric, Shaul, Jacob D., Huang, De-Bin, Ghosh, Gourisankar, Huxford, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977576/ https://www.ncbi.nlm.nih.gov/pubmed/24611898 http://dx.doi.org/10.1021/bi401551r

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