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Quantification of Transthyretin Kinetic Stability in Human Plasma Using Subunit Exchange
[Image: see text] The transthyretin (TTR) amyloidoses are a group of degenerative diseases caused by TTR aggregation, requiring rate-limiting tetramer dissociation. Kinetic stabilization of TTR, by preferential binding of a drug to the native tetramer over the dissociative transition state, dramatic...
Autores principales: | Rappley, Irit, Monteiro, Cecília, Novais, Marta, Baranczak, Aleksandra, Solis, Gregory, Wiseman, R. Luke, Helmke, Stephen, Maurer, Mathew S., Coelho, Teresa, Powers, Evan T., Kelly, Jeffery W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977577/ https://www.ncbi.nlm.nih.gov/pubmed/24661308 http://dx.doi.org/10.1021/bi500171j |
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