Cargando…

Amphipathic Polymers Enable the Study of Functional Membrane Proteins in the Gas Phase

[Image: see text] Membrane proteins are notoriously challenging to analyze using mass spectrometry (MS) because of their insolubility in aqueous solution. Current MS methods for studying intact membrane proteins involve solubilization in detergent. However, detergents can destabilize proteins, leadi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leney, Aneika C., McMorran, Lindsay M., Radford, Sheena E., Ashcroft, Alison E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2012
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977578/ https://www.ncbi.nlm.nih.gov/pubmed/23072351 http://dx.doi.org/10.1021/ac302223s

Ejemplares similares

Systematic analysis of the use of amphipathic polymers for studies of outer membrane proteins using mass spectrometry
por: Watkinson, Thomas G., et al.
Publicado: (2015)

Mechanistic studies of the biogenesis and folding of outer membrane proteins in vitro and in vivo: What have we learned to date?
por: McMorran, Lindsay M., et al.
Publicado: (2014)

Dissecting the Effects of Periplasmic Chaperones on the In Vitro Folding of the Outer Membrane Protein PagP
por: McMorran, Lindsay M., et al.
Publicado: (2013)

Amphipols Outperform Dodecylmaltoside Micelles in Stabilizing Membrane Protein Structure in the Gas Phase
por: Calabrese, Antonio N., et al.
Publicado: (2014)

Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry
por: Leney, Aneika C., et al.
Publicado: (2014)

Second Order Rate Constants of Donor-Strand Exchange Reveal Individual Amino Acid Residues Important in Determining the Subunit Specificity of Pilus Biogenesis
por: Leney, Aneika C., et al.
Publicado: (2011)

The Role of Chaperone-subunit Usher Domain Interactions in the Mechanism of Bacterial Pilus Biogenesis Revealed by ESI-MS
por: Morrissey, Bethny, et al.
Publicado: (2012)

An amphipathic helix enables septins to sense micrometer-scale membrane curvature
por: Cannon, Kevin S., et al.
Publicado: (2019)

Current Developments in Native Nanometric Discoidal Membrane Bilayer Formed by Amphipathic Polymers
por: Esmaili, Mansoore, et al.
Publicado: (2021)

Amphipathic Peptides Impede Lipid Domain Fusion in Phase-Separated Membranes
por: Pinigin, Konstantin V., et al.
Publicado: (2021)

FPOP-LC-MS/MS Suggests Differences in Interaction Sites of Amphipols and Detergents with Outer Membrane Proteins
por: Watkinson, Thomas G., et al.
Publicado: (2016)

Prediction of amphipathic helix—membrane interactions with Rosetta
por: Gulsevin, Alican, et al.
Publicado: (2021)

Skp is a multivalent chaperone of outer membrane proteins
por: Schiffrin, Bob, et al.
Publicado: (2016)

Membrane Curvature Sensing by Amphipathic Helices Is Modulated by the Surrounding Protein Backbone
por: Doucet, Christine M., et al.
Publicado: (2015)

Protein Amphipathic Helix Insertion: A Mechanism to Induce Membrane Fission
por: Zhukovsky, Mikhail A., et al.
Publicado: (2019)

Subunit pI Can Influence Protein Complex Dissociation Characteristics
por: Leney, Aneika C.
Publicado: (2019)

Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS
por: Devine, Paul W. A., et al.
Publicado: (2017)

Membrane Thinning and Thickening Induced by Membrane-Active Amphipathic Peptides
por: Grage, Stephan L., et al.
Publicado: (2016)

Effects of Periplasmic Chaperones and Membrane Thickness on BamA-Catalyzed Outer-Membrane Protein Folding
por: Schiffrin, Bob, et al.
Publicado: (2017)

Machine learning enables interpretable discovery of innovative polymers for gas separation membranes
por: Yang, Jason, et al.
Publicado: (2022)

Conformational flexibility within the nascent polypeptide–associated complex enables its interactions with structurally diverse client proteins
por: Martin, Esther M., et al.
Publicado: (2018)

Delamination of the Annulus Fibrosus of the Intervertebral Disc: Using a Bovine Tail Model to Examine Effect of Separation Rate
por: Briar, K. Josh, et al.
Publicado: (2022)

Using hydroxyl radical footprinting to explore the free energy landscape of protein folding
por: Calabrese, Antonio N., et al.
Publicado: (2015)

Comparing Hydrogen Deuterium Exchange and Fast Photochemical Oxidation of Proteins: a Structural Characterisation of Wild-Type and ΔN6 β(2)-Microglobulin
por: Cornwell, Owen, et al.
Publicado: (2018)

Making water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy
por: Mizrachi, Dario, et al.
Publicado: (2015)

Chirality-Dependent Adsorption between Amphipathic Peptide and POPC Membrane
por: Chen, Ke, et al.
Publicado: (2019)

Role of Amphipathic Helix of a Herpesviral Protein in Membrane Deformation and T Cell Receptor Downregulation
por: Min, Chan-Ki, et al.
Publicado: (2008)

Prediction of amphipathic in-plane membrane anchors in monotopic proteins using a SVM classifier
por: Sapay, Nicolas, et al.
Publicado: (2006)

Synthesis and Evaluation of a Library of Alternating Amphipathic Copolymers to Solubilize and Study Membrane Proteins
por: Kopf, Adrian H., et al.
Publicado: (2022)

HDX-ESI-MS Reveals Enhanced Conformational Dynamics of the Amyloidogenic Protein β(2)-Microglobulin upon Release from the MHC-1
por: Hodkinson, John P., et al.
Publicado: (2009)

Amphipathic polymer-mediated uptake of trehalose for dimethyl sulfoxide-free human cell cryopreservation()()
por: Sharp, Duncan M.C., et al.
Publicado: (2013)

New insights into the protective power of platelets in malaria infection
por: McMorran, Brendan J., et al.
Publicado: (2013)

The role of conformational flexibility in β(2)-microglobulin amyloid fibril formation at neutral pH
por: Hodkinson, John P, et al.
Publicado: (2012)

Changes in protein structure monitored by use of gas‐phase hydrogen/deuterium exchange
por: Beeston, Helen S., et al.
Publicado: (2015)

Membrane Fission Is Promoted by Insertion of Amphipathic Helices and Is Restricted by Crescent BAR Domains
por: Boucrot, Emmanuel, et al.
Publicado: (2012)

Cationic amphipathic peptides accumulate sialylated proteins and lipids in the plasma membrane of eukaryotic host cells
por: Weghuber, Julian, et al.
Publicado: (2011)

Membrane Thinning Induces Sorting of Lipids and the Amphipathic Lipid Packing Sensor (ALPS) Protein Motif
por: van Hilten, Niek, et al.
Publicado: (2020)

Investigation of D76N β(2)-Microglobulin Using Protein Footprinting and Structural Mass Spectrometry
por: Cornwell, Owen, et al.
Publicado: (2021)

Identification of an amphipathic peptide sensor of the Bacillus subtilis fluid membrane microdomains
por: Jiang, Yiping, et al.
Publicado: (2019)

Amphipathic Janus Membrane with Hierarchical Multiscale Hyperporous Structure for Interfacial Catalysis
por: Lin, Yakai, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9pr86ug7fcffr3ojrs9bqb2ark