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Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism

BACKGROUND: Increasing evidence of autoimmune phenomena in some individuals with autism could represent the presence of altered or inappropriate immune responses in this disorder. The role of the nucleosome in the induction of antibody response in some autoimmune-mediated tissue damage may provide n...

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Autores principales: AL-Ayadhi, Laila Yousef, Mostafa, Gehan Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977681/
https://www.ncbi.nlm.nih.gov/pubmed/24708718
http://dx.doi.org/10.1186/1742-2094-11-69
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author AL-Ayadhi, Laila Yousef
Mostafa, Gehan Ahmed
author_facet AL-Ayadhi, Laila Yousef
Mostafa, Gehan Ahmed
author_sort AL-Ayadhi, Laila Yousef
collection PubMed
description BACKGROUND: Increasing evidence of autoimmune phenomena in some individuals with autism could represent the presence of altered or inappropriate immune responses in this disorder. The role of the nucleosome in the induction of antibody response in some autoimmune-mediated tissue damage may provide novel targets for treatment. Due to the paucity of studies investigating the frequency of systemic auto-antibodies in autism, we are the first to investigate the frequency of antinucleosome-specific antibodies in a group of autistic children. METHODS: Serum antinucleosome-specific antibodies were measured by ELISA in 60 autistic children, between the ages of 3 and 12 years, in comparison to 60 healthy children. Autistic severity was assessed using the Childhood Autism Rating Scale (CARS). RESULTS: Autistic children had significantly higher serum antinucleosome-specific antibodies than healthy children (P <0.001). The seropositivity of antinucleosome-specific antibodies was found in 46.7% of autistic children. Autistic children with a family history of autoimmunity (40%) had a significantly higher frequency of serum antinucleosome-specific antibodies (83.3%) than patients without such a history (22.2%, P <0.001). CONCLUSIONS: Serum levels of antinucleosome-specific antibodies were increased in some autistic children. However, these data should be treated with caution until further investigations are performed with a larger subject population to determine whether these antibodies have a role in the induction of autoimmunity in a subgroup of autistic children. The role of immunotherapy in children with autism should be also studied.
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spelling pubmed-39776812014-04-08 Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism AL-Ayadhi, Laila Yousef Mostafa, Gehan Ahmed J Neuroinflammation Research BACKGROUND: Increasing evidence of autoimmune phenomena in some individuals with autism could represent the presence of altered or inappropriate immune responses in this disorder. The role of the nucleosome in the induction of antibody response in some autoimmune-mediated tissue damage may provide novel targets for treatment. Due to the paucity of studies investigating the frequency of systemic auto-antibodies in autism, we are the first to investigate the frequency of antinucleosome-specific antibodies in a group of autistic children. METHODS: Serum antinucleosome-specific antibodies were measured by ELISA in 60 autistic children, between the ages of 3 and 12 years, in comparison to 60 healthy children. Autistic severity was assessed using the Childhood Autism Rating Scale (CARS). RESULTS: Autistic children had significantly higher serum antinucleosome-specific antibodies than healthy children (P <0.001). The seropositivity of antinucleosome-specific antibodies was found in 46.7% of autistic children. Autistic children with a family history of autoimmunity (40%) had a significantly higher frequency of serum antinucleosome-specific antibodies (83.3%) than patients without such a history (22.2%, P <0.001). CONCLUSIONS: Serum levels of antinucleosome-specific antibodies were increased in some autistic children. However, these data should be treated with caution until further investigations are performed with a larger subject population to determine whether these antibodies have a role in the induction of autoimmunity in a subgroup of autistic children. The role of immunotherapy in children with autism should be also studied. BioMed Central 2014-04-03 /pmc/articles/PMC3977681/ /pubmed/24708718 http://dx.doi.org/10.1186/1742-2094-11-69 Text en Copyright © 2014 AL-Ayadhi and Mostafa; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
AL-Ayadhi, Laila Yousef
Mostafa, Gehan Ahmed
Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism
title Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism
title_full Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism
title_fullStr Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism
title_full_unstemmed Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism
title_short Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism
title_sort serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977681/
https://www.ncbi.nlm.nih.gov/pubmed/24708718
http://dx.doi.org/10.1186/1742-2094-11-69
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