Divergent RNA transcription: A role in promoter unwinding?

New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction. We explore a hypothesis that divergent RNA transcription generates negative supercoiling at promote...

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Detalles Bibliográficos
Autores principales: Naughton, Catherine, Corless, Samuel, Gilbert, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977915/
https://www.ncbi.nlm.nih.gov/pubmed/23863199
http://dx.doi.org/10.4161/trns.25554
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author Naughton, Catherine
Corless, Samuel
Gilbert, Nick
author_facet Naughton, Catherine
Corless, Samuel
Gilbert, Nick
author_sort Naughton, Catherine
collection PubMed
description New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction. We explore a hypothesis that divergent RNA transcription generates negative supercoiling at promoters facilitating initiation complex formation and subsequent promoter clearance.
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spelling pubmed-39779152014-04-14 Divergent RNA transcription: A role in promoter unwinding? Naughton, Catherine Corless, Samuel Gilbert, Nick Transcription Point of View New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction. We explore a hypothesis that divergent RNA transcription generates negative supercoiling at promoters facilitating initiation complex formation and subsequent promoter clearance. Landes Bioscience 2013-07-01 2013-07-25 /pmc/articles/PMC3977915/ /pubmed/23863199 http://dx.doi.org/10.4161/trns.25554 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Point of View
Naughton, Catherine
Corless, Samuel
Gilbert, Nick
Divergent RNA transcription: A role in promoter unwinding?
title Divergent RNA transcription: A role in promoter unwinding?
title_full Divergent RNA transcription: A role in promoter unwinding?
title_fullStr Divergent RNA transcription: A role in promoter unwinding?
title_full_unstemmed Divergent RNA transcription: A role in promoter unwinding?
title_short Divergent RNA transcription: A role in promoter unwinding?
title_sort divergent rna transcription: a role in promoter unwinding?
topic Point of View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977915/
https://www.ncbi.nlm.nih.gov/pubmed/23863199
http://dx.doi.org/10.4161/trns.25554
work_keys_str_mv AT naughtoncatherine divergentrnatranscriptionaroleinpromoterunwinding
AT corlesssamuel divergentrnatranscriptionaroleinpromoterunwinding
AT gilbertnick divergentrnatranscriptionaroleinpromoterunwinding

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