Cargando…

Identification of Direct and Indirect Social Network Effects in the Pathophysiology of Insulin Resistance in Obese Human Subjects

OBJECTIVE: The aim of the present study was to examine to what extent different social network mechanisms are involved in the pathogenesis of obesity and insulin-resistance. DESIGN: We used nonparametric and parametric regression models to analyse whether individual BMI and HOMA-IR are determined by...

Descripción completa

Detalles Bibliográficos
Autores principales: Henning, Christian H. C. A., Zarnekow, Nana, Hedtrich, Johannes, Stark, Sascha, Türk, Kathrin, Laudes, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977927/
https://www.ncbi.nlm.nih.gov/pubmed/24710599
http://dx.doi.org/10.1371/journal.pone.0093860
_version_ 1782310479269462016
author Henning, Christian H. C. A.
Zarnekow, Nana
Hedtrich, Johannes
Stark, Sascha
Türk, Kathrin
Laudes, Matthias
author_facet Henning, Christian H. C. A.
Zarnekow, Nana
Hedtrich, Johannes
Stark, Sascha
Türk, Kathrin
Laudes, Matthias
author_sort Henning, Christian H. C. A.
collection PubMed
description OBJECTIVE: The aim of the present study was to examine to what extent different social network mechanisms are involved in the pathogenesis of obesity and insulin-resistance. DESIGN: We used nonparametric and parametric regression models to analyse whether individual BMI and HOMA-IR are determined by social network characteristics. SUBJECTS AND METHODS: A total of 677 probands (EGO) and 3033 social network partners (ALTER) were included in the study. Data gathered from the probands include anthropometric measures, HOMA-IR index, health attitudes, behavioural and socio-economic variables and social network data. RESULTS: We found significant treatment effects for ALTERs frequent dieting (p<0.001) and ALTERs health oriented nutritional attitudes (p<0.001) on EGO's BMI, establishing a significant indirect network effect also on EGO's insulin resistance. Most importantly, we also found significant direct social network effects on EGO's insulin resistance, evidenced by an effect of ALTERs frequent dieting (p = 0.033) and ALTERs sport activities (p = 0.041) to decrease EGO's HOMA-IR index independently of EGO's BMI. CONCLUSIONS: Social network phenomena appear not only to be relevant for the spread of obesity, but also for the spread of insulin resistance as the basis for type 2 diabetes. Attitudes and behaviour of peer groups influence EGO's health status not only via social mechanisms, but also via socio-biological mechanisms, i.e. higher brain areas might be influenced not only by biological signals from the own organism, but also by behaviour and knowledge from different human individuals. Our approach allows the identification of peer group influence controlling for potential homophily even when using cross-sectional observational data.
format Online
Article
Text
id pubmed-3977927
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-39779272014-04-11 Identification of Direct and Indirect Social Network Effects in the Pathophysiology of Insulin Resistance in Obese Human Subjects Henning, Christian H. C. A. Zarnekow, Nana Hedtrich, Johannes Stark, Sascha Türk, Kathrin Laudes, Matthias PLoS One Research Article OBJECTIVE: The aim of the present study was to examine to what extent different social network mechanisms are involved in the pathogenesis of obesity and insulin-resistance. DESIGN: We used nonparametric and parametric regression models to analyse whether individual BMI and HOMA-IR are determined by social network characteristics. SUBJECTS AND METHODS: A total of 677 probands (EGO) and 3033 social network partners (ALTER) were included in the study. Data gathered from the probands include anthropometric measures, HOMA-IR index, health attitudes, behavioural and socio-economic variables and social network data. RESULTS: We found significant treatment effects for ALTERs frequent dieting (p<0.001) and ALTERs health oriented nutritional attitudes (p<0.001) on EGO's BMI, establishing a significant indirect network effect also on EGO's insulin resistance. Most importantly, we also found significant direct social network effects on EGO's insulin resistance, evidenced by an effect of ALTERs frequent dieting (p = 0.033) and ALTERs sport activities (p = 0.041) to decrease EGO's HOMA-IR index independently of EGO's BMI. CONCLUSIONS: Social network phenomena appear not only to be relevant for the spread of obesity, but also for the spread of insulin resistance as the basis for type 2 diabetes. Attitudes and behaviour of peer groups influence EGO's health status not only via social mechanisms, but also via socio-biological mechanisms, i.e. higher brain areas might be influenced not only by biological signals from the own organism, but also by behaviour and knowledge from different human individuals. Our approach allows the identification of peer group influence controlling for potential homophily even when using cross-sectional observational data. Public Library of Science 2014-04-07 /pmc/articles/PMC3977927/ /pubmed/24710599 http://dx.doi.org/10.1371/journal.pone.0093860 Text en © 2014 Henning et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Henning, Christian H. C. A.
Zarnekow, Nana
Hedtrich, Johannes
Stark, Sascha
Türk, Kathrin
Laudes, Matthias
Identification of Direct and Indirect Social Network Effects in the Pathophysiology of Insulin Resistance in Obese Human Subjects
title Identification of Direct and Indirect Social Network Effects in the Pathophysiology of Insulin Resistance in Obese Human Subjects
title_full Identification of Direct and Indirect Social Network Effects in the Pathophysiology of Insulin Resistance in Obese Human Subjects
title_fullStr Identification of Direct and Indirect Social Network Effects in the Pathophysiology of Insulin Resistance in Obese Human Subjects
title_full_unstemmed Identification of Direct and Indirect Social Network Effects in the Pathophysiology of Insulin Resistance in Obese Human Subjects
title_short Identification of Direct and Indirect Social Network Effects in the Pathophysiology of Insulin Resistance in Obese Human Subjects
title_sort identification of direct and indirect social network effects in the pathophysiology of insulin resistance in obese human subjects
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977927/
https://www.ncbi.nlm.nih.gov/pubmed/24710599
http://dx.doi.org/10.1371/journal.pone.0093860
work_keys_str_mv AT henningchristianhca identificationofdirectandindirectsocialnetworkeffectsinthepathophysiologyofinsulinresistanceinobesehumansubjects
AT zarnekownana identificationofdirectandindirectsocialnetworkeffectsinthepathophysiologyofinsulinresistanceinobesehumansubjects
AT hedtrichjohannes identificationofdirectandindirectsocialnetworkeffectsinthepathophysiologyofinsulinresistanceinobesehumansubjects
AT starksascha identificationofdirectandindirectsocialnetworkeffectsinthepathophysiologyofinsulinresistanceinobesehumansubjects
AT turkkathrin identificationofdirectandindirectsocialnetworkeffectsinthepathophysiologyofinsulinresistanceinobesehumansubjects
AT laudesmatthias identificationofdirectandindirectsocialnetworkeffectsinthepathophysiologyofinsulinresistanceinobesehumansubjects