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Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats

Decline in the ovarian hormones with menopause may influence somatosensory, cognitive, and affective processing. The present study investigated whether hormonal depletion alters the nociceptive, depressive-like and learning behaviors in experimental rats after ovariectomy (OVX), a common method to d...

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Autores principales: Li, Li-Hong, Wang, Zhe-Chen, Yu, Jin, Zhang, Yu-Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978042/
https://www.ncbi.nlm.nih.gov/pubmed/24710472
http://dx.doi.org/10.1371/journal.pone.0094312
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author Li, Li-Hong
Wang, Zhe-Chen
Yu, Jin
Zhang, Yu-Qiu
author_facet Li, Li-Hong
Wang, Zhe-Chen
Yu, Jin
Zhang, Yu-Qiu
author_sort Li, Li-Hong
collection PubMed
description Decline in the ovarian hormones with menopause may influence somatosensory, cognitive, and affective processing. The present study investigated whether hormonal depletion alters the nociceptive, depressive-like and learning behaviors in experimental rats after ovariectomy (OVX), a common method to deplete animals of their gonadal hormones. OVX rats developed thermal hyperalgesia in proximal and distal tail that was established 2 weeks after OVX and lasted the 7 weeks of the experiment. A robust mechanical allodynia was also occurred at 5 weeks after OVX. In the 5(th) week after OVX, dilute formalin (5%)-induced nociceptive responses (such as elevating and licking or biting) during the second phase were significantly increased as compared to intact and sham-OVX females. However, chronic constriction injury (CCI) of the sciatic nerve-induced mechanical allodynia did not differ as hormonal status (e.g. OVX and ovarian intact). Using formalin-induced conditioned place avoidance (F-CPA), which is believed to reflect the pain-related negative emotion, we further found that OVX significantly attenuated F-CPA scores but did not alter electric foot-shock-induced CPA (S-CPA). In the open field and forced swimming test, there was an increase in depressive-like behaviors in OVX rats. There was no detectable impairment of spatial performance by Morris water maze task in OVX rats up to 5 weeks after surgery. Estrogen replacement retrieved OVX-induced nociceptive hypersensitivity and depressive-like behaviors. This is the first study to investigate the impacts of ovarian removal on nociceptive perception, negative emotion, depressive-like behaviors and spatial learning in adult female rats in a uniform and standard way.
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spelling pubmed-39780422014-04-11 Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats Li, Li-Hong Wang, Zhe-Chen Yu, Jin Zhang, Yu-Qiu PLoS One Research Article Decline in the ovarian hormones with menopause may influence somatosensory, cognitive, and affective processing. The present study investigated whether hormonal depletion alters the nociceptive, depressive-like and learning behaviors in experimental rats after ovariectomy (OVX), a common method to deplete animals of their gonadal hormones. OVX rats developed thermal hyperalgesia in proximal and distal tail that was established 2 weeks after OVX and lasted the 7 weeks of the experiment. A robust mechanical allodynia was also occurred at 5 weeks after OVX. In the 5(th) week after OVX, dilute formalin (5%)-induced nociceptive responses (such as elevating and licking or biting) during the second phase were significantly increased as compared to intact and sham-OVX females. However, chronic constriction injury (CCI) of the sciatic nerve-induced mechanical allodynia did not differ as hormonal status (e.g. OVX and ovarian intact). Using formalin-induced conditioned place avoidance (F-CPA), which is believed to reflect the pain-related negative emotion, we further found that OVX significantly attenuated F-CPA scores but did not alter electric foot-shock-induced CPA (S-CPA). In the open field and forced swimming test, there was an increase in depressive-like behaviors in OVX rats. There was no detectable impairment of spatial performance by Morris water maze task in OVX rats up to 5 weeks after surgery. Estrogen replacement retrieved OVX-induced nociceptive hypersensitivity and depressive-like behaviors. This is the first study to investigate the impacts of ovarian removal on nociceptive perception, negative emotion, depressive-like behaviors and spatial learning in adult female rats in a uniform and standard way. Public Library of Science 2014-04-07 /pmc/articles/PMC3978042/ /pubmed/24710472 http://dx.doi.org/10.1371/journal.pone.0094312 Text en © 2014 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Li, Li-Hong
Wang, Zhe-Chen
Yu, Jin
Zhang, Yu-Qiu
Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats
title Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats
title_full Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats
title_fullStr Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats
title_full_unstemmed Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats
title_short Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats
title_sort ovariectomy results in variable changes in nociception, mood and depression in adult female rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978042/
https://www.ncbi.nlm.nih.gov/pubmed/24710472
http://dx.doi.org/10.1371/journal.pone.0094312
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