Cargando…

The Relationship between Serum 25-Hydroxyvitamin D, Parathyroid Hormone and the Glomerular Filtration Rate in Korean Adults: The Korea National Health and Nutrition Examination Survey between 2009 and 2011

BACKGROUND: The glomerular filtration rate (GFR) decreases with age, while parathyroid hormone (PTH) increases. There are a few reports only on the relationship between GFR and PTH under the category of serum 25-hydroxyvitamin D (25[OH]D) concentration. METHODS: Using the Korea National Health and N...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Sung-Woo, Kim, Sung-Jin, Lee, Duck-Joo, Kim, Kwang-Min, Joo, Nam-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Family Medicine 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978191/
https://www.ncbi.nlm.nih.gov/pubmed/24724005
http://dx.doi.org/10.4082/kjfm.2014.35.2.98
_version_ 1782310523307556864
author Han, Sung-Woo
Kim, Sung-Jin
Lee, Duck-Joo
Kim, Kwang-Min
Joo, Nam-Seok
author_facet Han, Sung-Woo
Kim, Sung-Jin
Lee, Duck-Joo
Kim, Kwang-Min
Joo, Nam-Seok
author_sort Han, Sung-Woo
collection PubMed
description BACKGROUND: The glomerular filtration rate (GFR) decreases with age, while parathyroid hormone (PTH) increases. There are a few reports only on the relationship between GFR and PTH under the category of serum 25-hydroxyvitamin D (25[OH]D) concentration. METHODS: Using the Korea National Health and Nutrition Examination Survey (KNHANES) data, a cross-sectional study was conducted on the association between serum 25(OH)D concentration, GFR and PTH in Korean adults aged 50 years or older. Serum PTH concentration was compared to the tertiles of GFR after adjustment for relevant variables. In addition, the serum PTH concentration was compared with the GFR under the category of serum 25(OH) D concentration (<20, 20-30, >30 ng/mL). RESULTS: The mean estimated GFR (eGFR) was 74.8 mL/min in men and 73.1 mL/min in women. The mean PTH and 25(OH) D was 66.8 pg/mL, 20.5 ng/mL in men and 69.0 pg/mL, 18.2 ng/mL in women. The serum PTH concentration showed a significant negative correlation with the serum 25(OH) D and eGFR in both genders. The serum PTH concentration significantly increased at the lower tertile of eGFR in male adults In addition, a decrease of serum PTH concentration was marked in the vitamin D sufficient male adults (>30 ng/mL). CONCLUSION: This present study demonstrated that serum PTH concentration showed negative correlation with eGFR, however, serum PTH increase may be minimized by maintaining proper serum 25(OH)D concentrations under similar eGFR status in Korean adults aged 50 and above.
format Online
Article
Text
id pubmed-3978191
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher The Korean Academy of Family Medicine
record_format MEDLINE/PubMed
spelling pubmed-39781912014-04-10 The Relationship between Serum 25-Hydroxyvitamin D, Parathyroid Hormone and the Glomerular Filtration Rate in Korean Adults: The Korea National Health and Nutrition Examination Survey between 2009 and 2011 Han, Sung-Woo Kim, Sung-Jin Lee, Duck-Joo Kim, Kwang-Min Joo, Nam-Seok Korean J Fam Med Original Article BACKGROUND: The glomerular filtration rate (GFR) decreases with age, while parathyroid hormone (PTH) increases. There are a few reports only on the relationship between GFR and PTH under the category of serum 25-hydroxyvitamin D (25[OH]D) concentration. METHODS: Using the Korea National Health and Nutrition Examination Survey (KNHANES) data, a cross-sectional study was conducted on the association between serum 25(OH)D concentration, GFR and PTH in Korean adults aged 50 years or older. Serum PTH concentration was compared to the tertiles of GFR after adjustment for relevant variables. In addition, the serum PTH concentration was compared with the GFR under the category of serum 25(OH) D concentration (<20, 20-30, >30 ng/mL). RESULTS: The mean estimated GFR (eGFR) was 74.8 mL/min in men and 73.1 mL/min in women. The mean PTH and 25(OH) D was 66.8 pg/mL, 20.5 ng/mL in men and 69.0 pg/mL, 18.2 ng/mL in women. The serum PTH concentration showed a significant negative correlation with the serum 25(OH) D and eGFR in both genders. The serum PTH concentration significantly increased at the lower tertile of eGFR in male adults In addition, a decrease of serum PTH concentration was marked in the vitamin D sufficient male adults (>30 ng/mL). CONCLUSION: This present study demonstrated that serum PTH concentration showed negative correlation with eGFR, however, serum PTH increase may be minimized by maintaining proper serum 25(OH)D concentrations under similar eGFR status in Korean adults aged 50 and above. The Korean Academy of Family Medicine 2014-03 2014-03-24 /pmc/articles/PMC3978191/ /pubmed/24724005 http://dx.doi.org/10.4082/kjfm.2014.35.2.98 Text en Copyright © 2014 The Korean Academy of Family Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Han, Sung-Woo
Kim, Sung-Jin
Lee, Duck-Joo
Kim, Kwang-Min
Joo, Nam-Seok
The Relationship between Serum 25-Hydroxyvitamin D, Parathyroid Hormone and the Glomerular Filtration Rate in Korean Adults: The Korea National Health and Nutrition Examination Survey between 2009 and 2011
title The Relationship between Serum 25-Hydroxyvitamin D, Parathyroid Hormone and the Glomerular Filtration Rate in Korean Adults: The Korea National Health and Nutrition Examination Survey between 2009 and 2011
title_full The Relationship between Serum 25-Hydroxyvitamin D, Parathyroid Hormone and the Glomerular Filtration Rate in Korean Adults: The Korea National Health and Nutrition Examination Survey between 2009 and 2011
title_fullStr The Relationship between Serum 25-Hydroxyvitamin D, Parathyroid Hormone and the Glomerular Filtration Rate in Korean Adults: The Korea National Health and Nutrition Examination Survey between 2009 and 2011
title_full_unstemmed The Relationship between Serum 25-Hydroxyvitamin D, Parathyroid Hormone and the Glomerular Filtration Rate in Korean Adults: The Korea National Health and Nutrition Examination Survey between 2009 and 2011
title_short The Relationship between Serum 25-Hydroxyvitamin D, Parathyroid Hormone and the Glomerular Filtration Rate in Korean Adults: The Korea National Health and Nutrition Examination Survey between 2009 and 2011
title_sort relationship between serum 25-hydroxyvitamin d, parathyroid hormone and the glomerular filtration rate in korean adults: the korea national health and nutrition examination survey between 2009 and 2011
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978191/
https://www.ncbi.nlm.nih.gov/pubmed/24724005
http://dx.doi.org/10.4082/kjfm.2014.35.2.98
work_keys_str_mv AT hansungwoo therelationshipbetweenserum25hydroxyvitamindparathyroidhormoneandtheglomerularfiltrationrateinkoreanadultsthekoreanationalhealthandnutritionexaminationsurveybetween2009and2011
AT kimsungjin therelationshipbetweenserum25hydroxyvitamindparathyroidhormoneandtheglomerularfiltrationrateinkoreanadultsthekoreanationalhealthandnutritionexaminationsurveybetween2009and2011
AT leeduckjoo therelationshipbetweenserum25hydroxyvitamindparathyroidhormoneandtheglomerularfiltrationrateinkoreanadultsthekoreanationalhealthandnutritionexaminationsurveybetween2009and2011
AT kimkwangmin therelationshipbetweenserum25hydroxyvitamindparathyroidhormoneandtheglomerularfiltrationrateinkoreanadultsthekoreanationalhealthandnutritionexaminationsurveybetween2009and2011
AT joonamseok therelationshipbetweenserum25hydroxyvitamindparathyroidhormoneandtheglomerularfiltrationrateinkoreanadultsthekoreanationalhealthandnutritionexaminationsurveybetween2009and2011
AT hansungwoo relationshipbetweenserum25hydroxyvitamindparathyroidhormoneandtheglomerularfiltrationrateinkoreanadultsthekoreanationalhealthandnutritionexaminationsurveybetween2009and2011
AT kimsungjin relationshipbetweenserum25hydroxyvitamindparathyroidhormoneandtheglomerularfiltrationrateinkoreanadultsthekoreanationalhealthandnutritionexaminationsurveybetween2009and2011
AT leeduckjoo relationshipbetweenserum25hydroxyvitamindparathyroidhormoneandtheglomerularfiltrationrateinkoreanadultsthekoreanationalhealthandnutritionexaminationsurveybetween2009and2011
AT kimkwangmin relationshipbetweenserum25hydroxyvitamindparathyroidhormoneandtheglomerularfiltrationrateinkoreanadultsthekoreanationalhealthandnutritionexaminationsurveybetween2009and2011
AT joonamseok relationshipbetweenserum25hydroxyvitamindparathyroidhormoneandtheglomerularfiltrationrateinkoreanadultsthekoreanationalhealthandnutritionexaminationsurveybetween2009and2011