BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups

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Langerhans cell histiocytosis (LCH) is a clonal disorder with elusive etiology, characterized by the accumulation of CD207(+) dendritic cells (DCs) in inflammatory lesions. Recurrent BRAF-V600E mutations have been reported in LCH. In this study, lesions from 100 patients were genotyped, and 64% carr...

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Detalles Bibliográficos
Autores principales: Berres, Marie-Luise, Lim, Karen Phaik Har, Peters, Tricia, Price, Jeremy, Takizawa, Hitoshi, Salmon, Hélène, Idoyaga, Juliana, Ruzo, Albert, Lupo, Philip J., Hicks, M. John, Shih, Albert, Simko, Stephen J., Abhyankar, Harshal, Chakraborty, Rikhia, Leboeuf, Marylene, Beltrão, Monique, Lira, Sérgio A., Heym, Kenneth M., Clausen, Björn E., Bigley, Venetia, Collin, Matthew, Manz, Markus G., McClain, Kenneth, Merad, Miriam, Allen, Carl E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978272/
https://www.ncbi.nlm.nih.gov/pubmed/24638167
http://dx.doi.org/10.1084/jem.20130977
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