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EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca(++), and Erk, leading to granule polarization
Ewing’s sarcoma-associated transcript 2 (EAT-2) is an Src homology 2 domain-containing intracellular adaptor related to signaling lymphocytic activation molecule (SLAM)–associated protein (SAP), the X-linked lymphoproliferative gene product. Both EAT-2 and SAP are expressed in natural killer (NK) ce...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978279/ https://www.ncbi.nlm.nih.gov/pubmed/24687958 http://dx.doi.org/10.1084/jem.20132038 |