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Dynamin 2–dependent endocytosis is required for sustained S1PR1 signaling

Sphingosine-1-phosphate (S1P) receptor 1 (S1PR1) is critical for lymphocyte egress from lymphoid organs. Lymphocytes encounter low S1P concentrations near exit sites before transmigration, yet S1PR1 signaling is rapidly terminated after exposure to S1P. How lymphocytes maintain S1PR1 signaling in a...

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Detalles Bibliográficos
Autores principales:	Willinger, Tim, Ferguson, Shawn M., Pereira, João P., De Camilli, Pietro, Flavell, Richard A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978280/ https://www.ncbi.nlm.nih.gov/pubmed/24638168 http://dx.doi.org/10.1084/jem.20131343

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