Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14

Several missense mutations in the protein kinase Cγ (γPKC) gene have been found to cause spinocerebellar ataxia type 14 (SCA14), an autosomal dominant neurodegenerative disease. γPKC is a neuron-specific member of the classical PKCs and is activated and translocated to subcellular regions as a resul...

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Detalles Bibliográficos
Autores principales: Yamamoto, Kazuhiro, Seki, Takahiro, Yamamoto, Hikaru, Adachi, Naoko, Tanaka, Shigeru, Hide, Izumi, Saito, Naoaki, Sakai, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978357/
https://www.ncbi.nlm.nih.gov/pubmed/24744737
http://dx.doi.org/10.3389/fphys.2014.00126

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