Cargando…

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

Neuritic plaques in the brain are a major neuropathological hallmark of Alzheimer’s disease. They are formed by the deposition and aggregation of extracellular amyloid-β protein (Aβ). Aβ is derived from the sequential cleavage of amyloid-β precursor protein (APP) by β-secretase and γ-secretase. β-Si...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xiaojie, Song, Weihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978418/ https://www.ncbi.nlm.nih.gov/pubmed/24103387 http://dx.doi.org/10.1186/alzrt211

Ejemplares similares

Surface Trafficking of APP and BACE in Live Cells
por: Bauereiss, Anna, et al.
Publicado: (2015)

Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production
por: Zhuravleva, Viktoriya, et al.
Publicado: (2021)

Icariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease
por: Zhang, Lan, et al.
Publicado: (2014)

DISC1 regulates trafficking and processing of APP and Aβ generation
por: Shahani, Neelam, et al.
Publicado: (2014)

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
por: Zhao, Yonghao, et al.
Publicado: (2012)

BACE overexpression alters the subcellular processing of APP and inhibits Aβ deposition in vivo
por: Lee, Edward B., et al.
Publicado: (2005)

The effect of BACE1-AS on β-amyloid generation by regulating BACE1 mRNA expression
por: Li, Fan, et al.
Publicado: (2019)

Segregation of the membrane cargoes, BACE1 and amyloid precursor protein (APP) throughout the Golgi apparatus
por: Fourriere, Lou, et al.
Publicado: (2022)

MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties
por: Chopra, Nipun, et al.
Publicado: (2020)

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease
por: Wang, Xin, et al.
Publicado: (2017)

Palmitoylated APP Forms Dimers, Cleaved by BACE1
por: Bhattacharyya, Raja, et al.
Publicado: (2016)

Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer’s mice
por: Li, Song, et al.
Publicado: (2015)

Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds
por: Gong, Li, et al.
Publicado: (2019)

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
por: Ulku, Irem, et al.
Publicado: (2023)

APP and Bace1: Differential effect of cholesterol enrichment on processing and plasma membrane mobility
por: Capitini, Claudia, et al.
Publicado: (2023)

BACE1 gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's disease
por: Sjölander, Annica, et al.
Publicado: (2010)

miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease
por: Barros-Viegas, Ana Teresa, et al.
Publicado: (2020)

Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production
por: Tan, Jing Zhi A., et al.
Publicado: (2020)

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice
por: Kim, WonHee, et al.
Publicado: (2018)

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)
por: von Einem, Bjoern, et al.
Publicado: (2015)

SPIN90 Deficiency Ameliorates Amyloid β Accumulation by Regulating APP Trafficking in AD Model Mice
por: Oh, Youngsoo, et al.
Publicado: (2022)

A lipid boundary separates APP and secretases and limits amyloid β-peptide generation
por: Kaether, Christoph, et al.
Publicado: (2004)

β-Amyloid precursor protein (APP) and the human diseases
por: Nguyen, Khue Vu
Publicado: (2019)

Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing
por: Wang, Yaqi, et al.
Publicado: (2022)

Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β
por: Menon, Preeti Kumaran, et al.
Publicado: (2019)

Deposition of BACE-1 Protein in the Brains of APP/PS1 Double Transgenic Mice
por: Luo, Gang, et al.
Publicado: (2016)

Intracellular Trafficking of the Amyloid β-Protein Precursor (APP) Regulated by Novel Function of X11-Like
por: Saito, Yuhki, et al.
Publicado: (2011)

Navβ2 knockdown improves cognition in APP/PS1 mice by partially inhibiting seizures and APP amyloid processing
por: Hu, Tao, et al.
Publicado: (2017)

Sorting out the cell biology of Alzheimer’s disease: focus on BACE1 and APP
por: Annaert, Wim
Publicado: (2012)

Visualization of APP and BACE-1 approximation in neurons: new insights into the amyloidogenic pathway
por: Das, Utpal, et al.
Publicado: (2015)

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level
por: Sadleir, Katherine R, et al.
Publicado: (2015)

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice
por: Neumann, Ulf, et al.
Publicado: (2015)

The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor
por: Youn, Kumju, et al.
Publicado: (2016)

Amyloid, APP, and Electrical Activity of the Brain
por: Hefter, Dimitri, et al.
Publicado: (2019)

Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane
por: Kaether, Christoph, et al.
Publicado: (2002)

Regulation of dynamic BACE1 trafficking in neurons
por: Buggia-Prévot, Virginie, et al.
Publicado: (2013)

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice
por: Steffen, Johannes, et al.
Publicado: (2017)

Dynamin 1 Regulates Amyloid Generation through Modulation of BACE-1
por: Zhu, Li, et al.
Publicado: (2012)

APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons
por: Roselli, Sandra, et al.
Publicado: (2023)

EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production
por: Nowakowska-Gołacka, Jowita, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_enkqvqjb4m9p3eq151dc1cmstg