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Periodontal disease, Porphyromonas gingivalis, and rheumatoid arthritis: what triggers autoimmunity and clinical disease?

Rheumatoid arthritis, currently regarded as a complex multifactorial disease, was initially characterized as such at the turn of the 19th century. Ever since, multiple lines of investigation have attempted to elucidate the etiological factor(s) involved in disease incidence. Genes – including those...

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Detalles Bibliográficos
Autores principales: Scher, Jose U, Abramson, Steven B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978430/
https://www.ncbi.nlm.nih.gov/pubmed/24229458
http://dx.doi.org/10.1186/ar4360
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author Scher, Jose U
Abramson, Steven B
author_facet Scher, Jose U
Abramson, Steven B
author_sort Scher, Jose U
collection PubMed
description Rheumatoid arthritis, currently regarded as a complex multifactorial disease, was initially characterized as such at the turn of the 19th century. Ever since, multiple lines of investigation have attempted to elucidate the etiological factor(s) involved in disease incidence. Genes – including those risk alleles within HLA-DR4 – have been implicated but are insufficient to explain the vast majority of cases. Several environmental factors, therefore, are being studied. Among them, the role of periodontal disease and Porphyromonas gingivalis in the pathogenesis of rheumatoid arthritis has attracted both clinical and bench interest given supportive epidemiologic and mechanistic data.
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spelling pubmed-39784302014-04-09 Periodontal disease, Porphyromonas gingivalis, and rheumatoid arthritis: what triggers autoimmunity and clinical disease? Scher, Jose U Abramson, Steven B Arthritis Res Ther Editorial Rheumatoid arthritis, currently regarded as a complex multifactorial disease, was initially characterized as such at the turn of the 19th century. Ever since, multiple lines of investigation have attempted to elucidate the etiological factor(s) involved in disease incidence. Genes – including those risk alleles within HLA-DR4 – have been implicated but are insufficient to explain the vast majority of cases. Several environmental factors, therefore, are being studied. Among them, the role of periodontal disease and Porphyromonas gingivalis in the pathogenesis of rheumatoid arthritis has attracted both clinical and bench interest given supportive epidemiologic and mechanistic data. BioMed Central 2013 2013-10-30 /pmc/articles/PMC3978430/ /pubmed/24229458 http://dx.doi.org/10.1186/ar4360 Text en Copyright © 2013 BioMed Central Ltd.
spellingShingle Editorial
Scher, Jose U
Abramson, Steven B
Periodontal disease, Porphyromonas gingivalis, and rheumatoid arthritis: what triggers autoimmunity and clinical disease?
title Periodontal disease, Porphyromonas gingivalis, and rheumatoid arthritis: what triggers autoimmunity and clinical disease?
title_full Periodontal disease, Porphyromonas gingivalis, and rheumatoid arthritis: what triggers autoimmunity and clinical disease?
title_fullStr Periodontal disease, Porphyromonas gingivalis, and rheumatoid arthritis: what triggers autoimmunity and clinical disease?
title_full_unstemmed Periodontal disease, Porphyromonas gingivalis, and rheumatoid arthritis: what triggers autoimmunity and clinical disease?
title_short Periodontal disease, Porphyromonas gingivalis, and rheumatoid arthritis: what triggers autoimmunity and clinical disease?
title_sort periodontal disease, porphyromonas gingivalis, and rheumatoid arthritis: what triggers autoimmunity and clinical disease?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978430/
https://www.ncbi.nlm.nih.gov/pubmed/24229458
http://dx.doi.org/10.1186/ar4360
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