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Non-site-specific allosteric effect of oxygen on human hemoglobin under high oxygen partial pressure

Protein allostery is essential for vital activities. Allosteric regulation of human hemoglobin (HbA) with two quaternary states T and R has been a paradigm of allosteric structural regulation of proteins. It is widely accepted that oxygen molecules (O(2)) act as a “site-specific” homotropic effector...

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Detalles Bibliográficos
Autores principales: Takayanagi, Masayoshi, Kurisaki, Ikuo, Nagaoka, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978498/
https://www.ncbi.nlm.nih.gov/pubmed/24710521
http://dx.doi.org/10.1038/srep04601

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