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Phototriggerable Liposomes: Current Research and Future Perspectives
The field of cancer nanomedicine is considered a promising area for improved delivery of bioactive molecules including drugs, pharmaceutical agents and nucleic acids. Among these, drug delivery technology has made discernible progress in recent years and the areas that warrant further focus and cons...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978522/ https://www.ncbi.nlm.nih.gov/pubmed/24662363 http://dx.doi.org/10.3390/pharmaceutics6010001 |
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author | Puri, Anu |
author_facet | Puri, Anu |
author_sort | Puri, Anu |
collection | PubMed |
description | The field of cancer nanomedicine is considered a promising area for improved delivery of bioactive molecules including drugs, pharmaceutical agents and nucleic acids. Among these, drug delivery technology has made discernible progress in recent years and the areas that warrant further focus and consideration towards technological developments have also been recognized. Development of viable methods for on-demand spatial and temporal release of entrapped drugs from the nanocarriers is an arena that is likely to enhance the clinical suitability of drug-loaded nanocarriers. One such approach, which utilizes light as the external stimulus to disrupt and/or destabilize drug-loaded nanoparticles, will be the discussion platform of this article. Although several phototriggerable nanocarriers are currently under development, I will limit this review to the phototriggerable liposomes that have demonstrated promise in the cell culture systems at least (but not the last). The topics covered in this review include (i) a brief summary of various phototriggerable nanocarriers; (ii) an overview of the application of liposomes to deliver payload of photosensitizers and associated technologies; (iii) the design considerations of photoactivable lipid molecules and the chemical considerations and mechanisms of phototriggering of liposomal lipids; (iv) limitations and future directions for in vivo, clinically viable triggered drug delivery approaches and potential novel photoactivation strategies will be discussed. |
format | Online Article Text |
id | pubmed-3978522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-39785222014-04-08 Phototriggerable Liposomes: Current Research and Future Perspectives Puri, Anu Pharmaceutics Review The field of cancer nanomedicine is considered a promising area for improved delivery of bioactive molecules including drugs, pharmaceutical agents and nucleic acids. Among these, drug delivery technology has made discernible progress in recent years and the areas that warrant further focus and consideration towards technological developments have also been recognized. Development of viable methods for on-demand spatial and temporal release of entrapped drugs from the nanocarriers is an arena that is likely to enhance the clinical suitability of drug-loaded nanocarriers. One such approach, which utilizes light as the external stimulus to disrupt and/or destabilize drug-loaded nanoparticles, will be the discussion platform of this article. Although several phototriggerable nanocarriers are currently under development, I will limit this review to the phototriggerable liposomes that have demonstrated promise in the cell culture systems at least (but not the last). The topics covered in this review include (i) a brief summary of various phototriggerable nanocarriers; (ii) an overview of the application of liposomes to deliver payload of photosensitizers and associated technologies; (iii) the design considerations of photoactivable lipid molecules and the chemical considerations and mechanisms of phototriggering of liposomal lipids; (iv) limitations and future directions for in vivo, clinically viable triggered drug delivery approaches and potential novel photoactivation strategies will be discussed. MDPI 2013-12-19 /pmc/articles/PMC3978522/ /pubmed/24662363 http://dx.doi.org/10.3390/pharmaceutics6010001 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Puri, Anu Phototriggerable Liposomes: Current Research and Future Perspectives |
title | Phototriggerable Liposomes: Current Research and Future Perspectives |
title_full | Phototriggerable Liposomes: Current Research and Future Perspectives |
title_fullStr | Phototriggerable Liposomes: Current Research and Future Perspectives |
title_full_unstemmed | Phototriggerable Liposomes: Current Research and Future Perspectives |
title_short | Phototriggerable Liposomes: Current Research and Future Perspectives |
title_sort | phototriggerable liposomes: current research and future perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978522/ https://www.ncbi.nlm.nih.gov/pubmed/24662363 http://dx.doi.org/10.3390/pharmaceutics6010001 |
work_keys_str_mv | AT purianu phototriggerableliposomescurrentresearchandfutureperspectives |