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Surface plasmon resonance using the catalytic domain of soluble guanylate cyclase allows the detection of enzyme activators()

Soluble Guanylate Cyclase (sGC) is the receptor for the signalling agent nitric oxide (NO) and catalyses the production of the second messenger cyclic guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). The enzyme is an attractive drug target for small molecules that act in the cardiov...

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Detalles Bibliográficos
Autores principales:	Mota, Filipa, Allerston, Charles K., Hampden-Smith, Kathryn, Garthwaite, John, Selwood, David L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Ltd 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978654/ https://www.ncbi.nlm.nih.gov/pubmed/24480469 http://dx.doi.org/10.1016/j.bmcl.2014.01.015

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