The Coriell personalized medicine collaborative pharmacogenomics appraisal, evidence scoring and interpretation system

Implementation of pharmacogenomics (PGx) in clinical care can lead to improved drug efficacy and reduced adverse drug reactions. However, there has been a lag in adoption of PGx tests in clinical practice. This is due in part to a paucity of rigorous systems for translating published clinical and sc...

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Autores principales: Gharani, Neda, Keller, Margaret A, Stack, Catharine B, Hodges, Laura M, Schmidlen, Tara J, Lynch, Daniel E, Gordon, Erynn S, Christman, Michael F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978656/
https://www.ncbi.nlm.nih.gov/pubmed/24134832
http://dx.doi.org/10.1186/gm499
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author Gharani, Neda
Keller, Margaret A
Stack, Catharine B
Hodges, Laura M
Schmidlen, Tara J
Lynch, Daniel E
Gordon, Erynn S
Christman, Michael F
author_facet Gharani, Neda
Keller, Margaret A
Stack, Catharine B
Hodges, Laura M
Schmidlen, Tara J
Lynch, Daniel E
Gordon, Erynn S
Christman, Michael F
author_sort Gharani, Neda
collection PubMed
description Implementation of pharmacogenomics (PGx) in clinical care can lead to improved drug efficacy and reduced adverse drug reactions. However, there has been a lag in adoption of PGx tests in clinical practice. This is due in part to a paucity of rigorous systems for translating published clinical and scientific data into standardized diagnostic tests with clear therapeutic recommendations. Here we describe the Pharmacogenomics Appraisal, Evidence Scoring and Interpretation System (PhAESIS), developed as part of the Coriell Personalized Medicine Collaborative research study, and its application to seven commonly prescribed drugs.
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spelling pubmed-39786562014-04-09 The Coriell personalized medicine collaborative pharmacogenomics appraisal, evidence scoring and interpretation system Gharani, Neda Keller, Margaret A Stack, Catharine B Hodges, Laura M Schmidlen, Tara J Lynch, Daniel E Gordon, Erynn S Christman, Michael F Genome Med Method Implementation of pharmacogenomics (PGx) in clinical care can lead to improved drug efficacy and reduced adverse drug reactions. However, there has been a lag in adoption of PGx tests in clinical practice. This is due in part to a paucity of rigorous systems for translating published clinical and scientific data into standardized diagnostic tests with clear therapeutic recommendations. Here we describe the Pharmacogenomics Appraisal, Evidence Scoring and Interpretation System (PhAESIS), developed as part of the Coriell Personalized Medicine Collaborative research study, and its application to seven commonly prescribed drugs. BioMed Central 2013-10-18 /pmc/articles/PMC3978656/ /pubmed/24134832 http://dx.doi.org/10.1186/gm499 Text en Copyright © 2013 Gharani et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Method
Gharani, Neda
Keller, Margaret A
Stack, Catharine B
Hodges, Laura M
Schmidlen, Tara J
Lynch, Daniel E
Gordon, Erynn S
Christman, Michael F
The Coriell personalized medicine collaborative pharmacogenomics appraisal, evidence scoring and interpretation system
title The Coriell personalized medicine collaborative pharmacogenomics appraisal, evidence scoring and interpretation system
title_full The Coriell personalized medicine collaborative pharmacogenomics appraisal, evidence scoring and interpretation system
title_fullStr The Coriell personalized medicine collaborative pharmacogenomics appraisal, evidence scoring and interpretation system
title_full_unstemmed The Coriell personalized medicine collaborative pharmacogenomics appraisal, evidence scoring and interpretation system
title_short The Coriell personalized medicine collaborative pharmacogenomics appraisal, evidence scoring and interpretation system
title_sort coriell personalized medicine collaborative pharmacogenomics appraisal, evidence scoring and interpretation system
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978656/
https://www.ncbi.nlm.nih.gov/pubmed/24134832
http://dx.doi.org/10.1186/gm499
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