Cargando…

Molecular targeting of hepatocyte growth factor by an antagonist, NK4, in the treatment of rheumatoid arthritis

INTRODUCTION: Hepatocyte growth factor (HGF) is a potent proangiogenic molecule that induces neovascularization. The HGF antagonist, NK4, competitively antagonizes HGF binding to its receptor. In the present study, we determined the inhibitory effect of NK4 in a rheumatoid arthritis (RA) model using...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsunemi, Sachi, Iwasaki, Tsuyoshi, Kitano, Sachie, Matsumoto, Kunio, Takagi-Kimura, Misato, Kubo, Shuji, Tamaoki, Tomoko, Sano, Hajime
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978668/ https://www.ncbi.nlm.nih.gov/pubmed/23876175 http://dx.doi.org/10.1186/ar4252

Ejemplares similares

Differential regulation of c-Met signaling pathways for synovial cell function
por: Shibasaki, Seiji, et al.
Publicado: (2014)

Blocking c-Met signaling enhances bone morphogenetic protein-2-induced osteoblast differentiation
por: Shibasaki, Seiji, et al.
Publicado: (2015)

Hepatocyte growth factor ameliorates dermal sclerosis in the tight-skin mouse model of scleroderma
por: Iwasaki, Tsuyoshi, et al.
Publicado: (2006)

Effect of transient expression of fluorescent protein probes in synovial and myoblast cell lines
por: Shibasaki, Seiji, et al.
Publicado: (2012)

Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors
por: Kubo, Shuji, et al.
Publicado: (2018)

A comparative proteomics study of a synovial cell line stimulated with TNF‐α
por: Shibasaki, Seiji, et al.
Publicado: (2016)

Dual-vector prodrug activator gene therapy using retroviral replicating vectors
por: Kubo, Shuji, et al.
Publicado: (2018)

Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2
Publicado: (1996)

Hepatocyte growth factor prevents lupus nephritis in a murine lupus model of chronic graft-versus-host disease
por: Kuroiwa, Takanori, et al.
Publicado: (2006)

Rotor Syndrome: Glucuronidated Bile Acidemia From Defective Reuptake by Hepatocytes
por: Kimura, Akihiko, et al.
Publicado: (2020)

Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies
por: Umitsu, Masataka, et al.
Publicado: (2016)

De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist
por: Komatsu, Yamato, et al.
Publicado: (2021)

Role of Hepatocyte Growth Regulators in Liver Regeneration
por: Kimura, Mitsutoshi, et al.
Publicado: (2023)

Hepato‐entrained B220(+) CD11c(+) NK1.1(+) cells regulate pre‐metastatic niche formation in the lung
por: Hiratsuka, Sachie, et al.
Publicado: (2018)

Hepatocyte growth factor/MET in cancer progression and biomarker discovery
por: Matsumoto, Kunio, et al.
Publicado: (2017)

NK-1 Receptor Antagonists and Pruritus: Review of Current Literature
por: Pojawa-Gołąb, Marcelina, et al.
Publicado: (2019)

The hepatocyte growth factor antagonist NK4 inhibits indoleamine-2,3-dioxygenase expression via the c-Met-phosphatidylinositol 3-kinase-AKT signaling pathway
por: WANG, DONGDONG, et al.
Publicado: (2016)

Genetic Abolishment of Hepatocyte Proliferation Activates Hepatic Stem Cells
por: Endo, Yoko, et al.
Publicado: (2012)

NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells
por: Maehara, N, et al.
Publicado: (2001)

Dimer Interface in Natural Variant NK1 Is Dispensable for HGF-Dependent Met Receptor Activation
por: Tahira, Yumiko, et al.
Publicado: (2021)

Induction of Invasive Growth in a Gallbladder Cancer Cell Line by Hepatocyte Growth Factor in vitro
por: Shimura, Hideo, et al.
Publicado: (1995)

Effect of TNF antagonists on the productivity of daily work of patients with rheumatoid arthritis
por: Furuya, Hidekazu, et al.
Publicado: (2013)

Clinicopathological findings, prognosis, and Epstein–Barr virus infection in rheumatoid arthritis patients with other iatrogenic immunodeficiency-associated T- and NK-cell lymphoproliferative disorders
por: Kimura, Shoichi, et al.
Publicado: (2022)

Impaired NK and NKT cells immunobiology in rheumatoid arthritis
por: Aggarwal, Ashish, et al.
Publicado: (2012)

The NK1 antagonist L-733,060 facilitates sequence learning
por: Favila, Natalia, et al.
Publicado: (2023)

Acquisition of Invasive Phenotype in Gallbladder Cancer Cells via Mutual Interaction of Stromal Fibroblasts and Cancer Cells as Mediated by Hepatocyte Growth Factor
por: Matsumoto, Kunio, et al.
Publicado: (1996)

Current position of 5HT(3) antagonists and the additional value of NK(1) antagonists; a new class of antiemetics
por: de Wit, R
Publicado: (2003)

Immunohistochemical Localization of Hepatocyte Growth Factor Protein in Pancreas Islet A‐Cells of Man and Rats
por: Tsuda, Hiroyuki, et al.
Publicado: (1992)

Effect of casopitant, a novel NK-1 antagonist, on the pharmacokinetics of dolasetron and granisetron
por: Adams, Laurel M., et al.
Publicado: (2009)

Impact of casopitant, a novel NK-1 antagonist, on the pharmacokinetics of ondansetron and dexamethasone
por: Johnson, Brendan, et al.
Publicado: (2009)

Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV
por: Barrett, Jeffrey S., et al.
Publicado: (2016)

Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity
por: Recio, Rocío, et al.
Publicado: (2021)

Evaluation of tradipitant, a selective NK1 antagonist, on response to oxycodone in humans
por: Coe, Marion A., et al.
Publicado: (2021)

Hepatocyte-specific NEMO deletion promotes NK/NKT cell– and TRAIL-dependent liver damage
por: Beraza, Naiara, et al.
Publicado: (2009)

Prolonged Survival in a Case of Chemotherapy-Sensitive Gastric Cancer That Produced Alpha-Fetoprotein and Protein Induced by Vitamin K Antagonist-II
por: Ogasawara, Naotaka, et al.
Publicado: (2015)

Prevention of chemotherapy-induced nausea: the role of neurokinin-1 (NK(1)) receptor antagonists
por: Bošnjak, Snežana M., et al.
Publicado: (2017)

NK1 antagonists attenuate tau phosphorylation after blast and repeated concussive injury
por: Corrigan, Frances, et al.
Publicado: (2021)

Relationship between rheumatoid arthritis and locomotive syndrome: validation of the 25-question Geriatric Locomotive Function Scale in patients with rheumatoid arthritis
por: Sobue, Yasumori, et al.
Publicado: (2019)

What is the future of CCR5 antagonists in rheumatoid arthritis?
por: Takeuchi, Tsutomu, et al.
Publicado: (2012)

The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis
por: Hashizume, Misato, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_76dus0oofol2sphq23q81t58o0