Inhibition of synovitis and joint destruction by a new single domain antibody specific for cyclophilin A in two different mouse models of rheumatoid arthritis

INTRODUCTION: Cyclophilin A (CypA) is implicated in rheumatoid arthritis (RA) pathogenesis. We studied whether a novel anti-CypA single domain antibody (sdAb) treatment would modulate the severity of the disease in two different animal models of RA. METHODS: A novel sdAb, named sdAbA1, was screened...

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Detalles Bibliográficos
Autores principales: Wang, Li, Jia, Junfeng, Wang, Conghua, Ma, Xiaokui, Liao, Chenggong, Fu, Zhiguang, Wang, Bin, Yang, Xiangmin, Zhu, Ping, Li, Yu, Chen, Zhinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978695/
https://www.ncbi.nlm.nih.gov/pubmed/24314202
http://dx.doi.org/10.1186/ar4401

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