Cargando…

Systemic sclerosis sera affect fibrillin-1 deposition by dermal blood microvascular endothelial cells: therapeutic implications of cyclophosphamide

INTRODUCTION: Systemic sclerosis (SSc) is a connective tissue disorder characterized by endothelial cell injury, autoimmunity and fibrosis. The following three fibrillin-1 alterations have been reported in SSc. (1) Fibrillin-1 microfibrils are disorganized in SSc dermis. (2) Fibrillin-1 microfibrils...

Descripción completa

Detalles Bibliográficos
Autores principales:	Villano, Marilisa, Borghini, Annalisa, Manetti, Mirko, Gabbrielli, Erica, Rossi, Antonella, Sestini, Piersante, Milia, Anna Franca, Nacci, Francesca, Guiducci, Serena, Matucci-Cerinic, Marco, Ibba-Manneschi, Lidia, Weber, Elisabetta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978697/ https://www.ncbi.nlm.nih.gov/pubmed/23962393 http://dx.doi.org/10.1186/ar4270

Ejemplares similares

Systemic Sclerosis Sera Impair Angiogenic Performance of Dermal Microvascular Endothelial Cells: Therapeutic Implications of Cyclophosphamide
por: Borghini, Annalisa, et al.
Publicado: (2015)

Mechanisms in the loss of capillaries in systemic sclerosis: angiogenesis versus vasculogenesis
por: Manetti, Mirko, et al.
Publicado: (2010)

Evidence for progressive reduction and loss of telocytes in the dermal cellular network of systemic sclerosis
por: Manetti, Mirko, et al.
Publicado: (2013)

Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells
por: Mazzotta, Celestina, et al.
Publicado: (2017)

Evidence for the prevention of enthesitis in HLA-B27/hβ(2)m transgenic rats treated with a monoclonal antibody against TNF-α
por: Milia, Anna Franca, et al.
Publicado: (2011)

A loss of telocytes accompanies fibrosis of multiple organs in systemic sclerosis
por: Manetti, Mirko, et al.
Publicado: (2014)

Scleroderma-like Impairment in the Network of Telocytes/CD34(+) Stromal Cells in the Experimental Mouse Model of Bleomycin-Induced Dermal Fibrosis
por: Rosa, Irene, et al.
Publicado: (2021)

TNFα blockade prevents the development of inflammatory bowel disease in HLA-B27 transgenic rats
por: Milia, Anna Franca, et al.
Publicado: (2009)

Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium
por: Terenzi, Riccardo, et al.
Publicado: (2017)

Impairment in the telocyte/CD34(+) stromal cell network in human rheumatoid arthritis synovium
por: Rosa, Irene, et al.
Publicado: (2020)

Systemic Sclerosis Serum Steers the Differentiation of Adipose-Derived Stem Cells Toward Profibrotic Myofibroblasts: Pathophysiologic Implications
por: Manetti, Mirko, et al.
Publicado: (2019)

Anti-Fas IgM monoclonal antibody (anti-Fas mAb) effect on haemophilic arthropathy (HA) synoviocytes
por: Guiducci, Serena, et al.
Publicado: (2012)

Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosis
por: Mazzotta, Celestina, et al.
Publicado: (2015)

A Two-Step Immunomagnetic Microbead-Based Method for the Isolation of Human Primary Skin Telocytes/CD34+ Stromal Cells
por: Romano, Eloisa, et al.
Publicado: (2020)

Angiogenic T cell expansion correlates with severity of peripheral vascular damage in systemic sclerosis
por: Manetti, Mirko, et al.
Publicado: (2017)

Systemic Sclerosis Serum Significantly Impairs the Multi-Step Lymphangiogenic Process: In Vitro Evidence
por: Manetti, Mirko, et al.
Publicado: (2019)

Decreased expression of the endothelial cell-derived factor EGFL7 in systemic sclerosis: potential contribution to impaired angiogenesis and vasculogenesis
por: Manetti, Mirko, et al.
Publicado: (2013)

The crowded crossroad to angiogenesis in systemic sclerosis: where is the key to the problem?
por: Manetti, Mirko, et al.
Publicado: (2016)

Telocytes in Crohn’s disease
por: Milia, Anna Franca, et al.
Publicado: (2013)

TNF-α/TNF-R System May Represent a Crucial Mediator of Proliferative Synovitis in Hemophilia A
por: Manetti, Mirko, et al.
Publicado: (2019)

In systemic sclerosis, levels of tissue kallikrein are related to microvascular changes assayed by videocapillaroscopy and immunohistochemistry
por: Rosso, A Del, et al.
Publicado: (2005)

Telocytes are reduced during fibrotic remodelling of the colonic wall in ulcerative colitis
por: Manetti, Mirko, et al.
Publicado: (2015)

Circulating Neurovascular Guidance Molecules and Their Relationship with Peripheral Microvascular Impairment in Systemic Sclerosis
por: Romano, Eloisa, et al.
Publicado: (2022)

Increased Circulating Soluble Junctional Adhesion Molecules in Systemic Sclerosis: Association with Peripheral Microvascular Impairment
por: Romano, Eloisa, et al.
Publicado: (2022)

Blockade of CCL24 with a monoclonal antibody ameliorates experimental dermal and pulmonary fibrosis
por: Mor, Adi, et al.
Publicado: (2019)

Pathophysiology of Hemophilic Arthropathy
por: Melchiorre, Daniela, et al.
Publicado: (2017)

Morphological evidence of telocytes in human synovium
por: Rosa, Irene, et al.
Publicado: (2018)

Telocytes constitute a widespread interstitial meshwork in the lamina propria and underlying striated muscle of human tongue
por: Rosa, Irene, et al.
Publicado: (2019)

Cyclophosphamide in systemic sclerosis: still in search of a 'real life' scenario
por: Miniati, Irene, et al.
Publicado: (2009)

Telocytes express PDGFRα in the human gastrointestinal tract
por: Vannucchi, Maria-Giuliana, et al.
Publicado: (2013)

Abnormal fibrillin assembly by dermal fibroblasts from two patients with Marfan syndrome
Publicado: (1994)

The contribution of epigenetics to the pathogenesis and gender dimorphism of systemic sclerosis: a comprehensive overview
por: Fioretto, Bianca Saveria, et al.
Publicado: (2020)

Telocytes in minor salivary glands of primary Sjögren’s syndrome: association with the extent of inflammation and ectopic lymphoid neogenesis
por: Alunno, Alessia, et al.
Publicado: (2015)

Mobilization of lymphatic endothelial precursor cells and lymphatic neovascularization in primary Sjögren's syndrome
por: Alunno, Alessia, et al.
Publicado: (2016)

Telocytes in normal and keratoconic human cornea: an immunohistochemical and transmission electron microscopy study
por: Marini, Mirca, et al.
Publicado: (2017)

Reappraising the microscopic anatomy of human testis: identification of telocyte networks in the peritubular and intertubular stromal space
por: Marini, Mirca, et al.
Publicado: (2018)

Morphologic evidence of telocytes in human thyroid stromal tissue
por: Rosa, Irene, et al.
Publicado: (2022)

New Insights into Profibrotic Myofibroblast Formation in Systemic Sclerosis: When the Vascular Wall Becomes the Enemy
por: Romano, Eloisa, et al.
Publicado: (2021)

Decreased Serum Levels of SIRT1 and SIRT3 Correlate with Severity of Skin and Lung Fibrosis and Peripheral Microvasculopathy in Systemic Sclerosis
por: Manetti, Mirko, et al.
Publicado: (2022)

Adipose-derived stem cells: Pathophysiologic implications vs therapeutic potential in systemic sclerosis
por: Rosa, Irene, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ks29sqkn7l0djdel17cfng4pjq