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A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells

INTRODUCTION: Increased expression of the proinflammatory cytokine TNF-α in intervertebral discs (IVDs) leads to inflammation, which results in progressive IVD degeneration. We have previously reported that activation of Wnt-β-catenin (hereafter called Wnt) signaling suppresses the proliferation of...

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Detalles Bibliográficos
Autores principales: Hiyama, Akihiko, Yokoyama, Katsuya, Nukaga, Tadashi, Sakai, Daisuke, Mochida, Joji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978705/
https://www.ncbi.nlm.nih.gov/pubmed/24286133
http://dx.doi.org/10.1186/ar4379