Small molecule inhibitors of WNT/β-catenin signaling block IL-1β- and TNFα-induced cartilage degradation

INTRODUCTION: In this study, we tested the ability of small molecule inhibitors of WNT/β-catenin signaling to block interleukin 1β (IL-1β)- and tumor necrosis factor α (TNFα)-induced cartilage degradation. Proinflammatory cytokines such as IL-1β and TNFα are potent inducers of cartilage degradation...

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Detalles Bibliográficos
Autores principales: Landman, Ellie BM, Miclea, Razvan L, van Blitterswijk, Clemens A, Karperien, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978727/
https://www.ncbi.nlm.nih.gov/pubmed/23965253
http://dx.doi.org/10.1186/ar4273

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