Cargando…

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors

INTRODUCTION: Osteoarthritis is, at least in a subset of patients, associated with hypertrophic differentiation of articular chondrocytes. Recently, we identified the bone morphogenetic protein (BMP) and wingless-type MMTV integration site (WNT) signaling antagonists Gremlin 1 (GREM1), frizzled-rela...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leijten, Jeroen CH, Bos, Steffan D, Landman, Ellie BM, Georgi, Nicole, Jahr, Holger, Meulenbelt, Ingrid, Post, Janine N, van Blitterswijk, Clemens A, Karperien, Marcel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978825/ https://www.ncbi.nlm.nih.gov/pubmed/24286177 http://dx.doi.org/10.1186/ar4306

Ejemplares similares

Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression
por: Zhong, Leilei, et al.
Publicado: (2017)

Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells
por: Zhong, Leilei, et al.
Publicado: (2016)

Small molecule inhibitors of WNT/β-catenin signaling block IL-1β- and TNFα-induced cartilage degradation
por: Landman, Ellie BM, et al.
Publicado: (2013)

Loss of Grem1-articular cartilage progenitor cells causes osteoarthritis
por: Ng, Jia Q., et al.
Publicado: (2023)

Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis
por: Ng, Jia Q., et al.
Publicado: (2023)

Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis
por: Tuerlings, Margo, et al.
Publicado: (2021)

Molecular mechanisms involved in a differential association of Frzb biology with osteoarthritis and osteoporosis
por: Lories, Rik JU, et al.
Publicado: (2007)

Hypoxia Inhibits Hypertrophic Differentiation and Endochondral Ossification in Explanted Tibiae
por: Leijten, Jeroen C. H., et al.
Publicado: (2012)

Correlation between Gene Expression and Osteoarthritis Progression in Human
por: Zhong, Leilei, et al.
Publicado: (2016)

CircCNIH4 inhibits gastric cancer progression via regulating DKK2 and FRZB expression and Wnt/β-catenin pathway
por: Shi, Qi, et al.
Publicado: (2021)

DNA Methylation in Osteoarthritis
por: den Hollander, Wouter, et al.
Publicado: (2015)

Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients
por: Honsawek, Sittisak, et al.
Publicado: (2010)

Functional analysis of the Frzb2 gene in Schistosoma japonicum
por: Cheng, Guifeng, et al.
Publicado: (2019)

BMP signalling in human fetal ovary somatic cells is modulated in a gene-specific fashion by GREM1 and GREM2
por: Bayne, Rosemary A., et al.
Publicado: (2016)

Distinct Effect of TCF4 on the NFκB Pathway in Human Primary Chondrocytes and the C20/A4 Chondrocyte Cell Line
por: Landman, E.B.M., et al.
Publicado: (2014)

Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease
por: Roxburgh, Sarah A., et al.
Publicado: (2009)

GREM 1 and POLE variants in hereditary colorectal cancer syndromes
por: Rohlin, Anna, et al.
Publicado: (2015)

Current status and prospects of GREM1 research in cancer (Review)
por: Zhu, Dantong, et al.
Publicado: (2023)

Early Determination of the Periodontal Domain by the Wnt-Antagonist Frzb/Sfrp3
por: Mitsiadis, Thimios A., et al.
Publicado: (2017)

Wattles in goats are associated with the FMN1/GREM1 region on chromosome 10
por: Reber, I., et al.
Publicado: (2015)

GREM1 is expressed in the cancer-associated myofibroblasts of basal cell carcinomas
por: Kim, Hye Sung, et al.
Publicado: (2017)

Nicotine exacerbates diabetic nephropathy through upregulation of Grem1 expression
por: Chen, Jianning, et al.
Publicado: (2023)

GREM1 is a potential biomarker for the progression and prognosis of bladder cancer
por: Jiang, Peng-cheng, et al.
Publicado: (2023)

Detecting early stage osteoarthritis by optical coherence tomography?
por: Jahr, Holger, et al.
Publicado: (2015)

Distinct roles of DKK1 and DKK2 in tumor angiogenesis
por: Park, Hongryeol, et al.
Publicado: (2013)

Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis
por: Kwan, Thaddaeus, et al.
Publicado: (2020)

FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity
por: Oh, Chang-Kyu, et al.
Publicado: (2021)

Genes Involved in the Osteoarthritis Process Identified through Genome Wide Expression Analysis in Articular Cartilage; the RAAK Study
por: Ramos, Yolande F. M., et al.
Publicado: (2014)

Drug Discovery of DKK1 Inhibitors
por: Jiang, Hewen, et al.
Publicado: (2022)

GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients
por: Neckmann, Ulrike, et al.
Publicado: (2019)

Increased hypospadias risk by GREM1 rs3743104[G] in the southern Han Chinese population
por: Deng, Fuming, et al.
Publicado: (2021)

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis
por: Bomer, Nils, et al.
Publicado: (2015)

An epigenome-wide view of osteoarthritis in primary tissues
por: Kreitmaier, Peter, et al.
Publicado: (2022)

Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration
por: Koppens, Martijn A. J., et al.
Publicado: (2021)

GREM1 is a novel serum diagnostic marker and potential therapeutic target for pancreatic ductal adenocarcinoma
por: Yang, Sen, et al.
Publicado: (2022)

GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis
por: Shi, Xiaoni, et al.
Publicado: (2022)

Hydrolytically Labile Linkers Regulate Release and Activity of Human Bone Morphogenetic Protein-6
por: Cabanas-Danés, Jordi, et al.
Publicado: (2018)

DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti‐DKK1 therapeutic DKN‐01
por: Jarman, Edward J., et al.
Publicado: (2022)

Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice
por: Lodewyckx, Liesbet, et al.
Publicado: (2012)

Olfactory ensheathing cells abutting the embryonic olfactory bulb express Frzb, whose deletion disrupts olfactory axon targeting
por: Rich, Constance A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rtmse6f0jq9a2ubmi4pberr2pt