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An emerging player in knee osteoarthritis: the infrapatellar fat pad

The role of inflammation in the development, progression, and clinical features of osteoarthritis has become an area of intense research in recent years. This led to the recognition of synovitis as an important source of inflammation in the joint and indicated that synovitis is intimately associated...

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Detalles Bibliográficos
Autores principales: Ioan-Facsinay, Andreea, Kloppenburg, Margreet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979009/
https://www.ncbi.nlm.nih.gov/pubmed/24367915
http://dx.doi.org/10.1186/ar4422
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author Ioan-Facsinay, Andreea
Kloppenburg, Margreet
author_facet Ioan-Facsinay, Andreea
Kloppenburg, Margreet
author_sort Ioan-Facsinay, Andreea
collection PubMed
description The role of inflammation in the development, progression, and clinical features of osteoarthritis has become an area of intense research in recent years. This led to the recognition of synovitis as an important source of inflammation in the joint and indicated that synovitis is intimately associated with pain and osteoarthritis progression. In this review, we discuss another emerging source of inflammation that could play a role in disease development/progression: the infrapatellar fat pad (IFP). The aim of this review is to offer a comprehensive view of the pathology of IFP as obtained from magnetic resonance studies, along with its characterization at both the cellular and the molecular level. Furthermore, we discuss the possible function of this organ in the pathological processes in the knee by summarizing the knowledge regarding the interactions between IFP and other joint tissues and discussing the pro- versus anti-inflammatory functions this tissue could have. We hope that this review will offer an overview of all published data regarding the IFP and will indicate novel directions for future research.
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spelling pubmed-39790092014-06-24 An emerging player in knee osteoarthritis: the infrapatellar fat pad Ioan-Facsinay, Andreea Kloppenburg, Margreet Arthritis Res Ther Review The role of inflammation in the development, progression, and clinical features of osteoarthritis has become an area of intense research in recent years. This led to the recognition of synovitis as an important source of inflammation in the joint and indicated that synovitis is intimately associated with pain and osteoarthritis progression. In this review, we discuss another emerging source of inflammation that could play a role in disease development/progression: the infrapatellar fat pad (IFP). The aim of this review is to offer a comprehensive view of the pathology of IFP as obtained from magnetic resonance studies, along with its characterization at both the cellular and the molecular level. Furthermore, we discuss the possible function of this organ in the pathological processes in the knee by summarizing the knowledge regarding the interactions between IFP and other joint tissues and discussing the pro- versus anti-inflammatory functions this tissue could have. We hope that this review will offer an overview of all published data regarding the IFP and will indicate novel directions for future research. BioMed Central 2013 2013-12-24 /pmc/articles/PMC3979009/ /pubmed/24367915 http://dx.doi.org/10.1186/ar4422 Text en Copyright © 2013 BioMed Central Ltd.
spellingShingle Review
Ioan-Facsinay, Andreea
Kloppenburg, Margreet
An emerging player in knee osteoarthritis: the infrapatellar fat pad
title An emerging player in knee osteoarthritis: the infrapatellar fat pad
title_full An emerging player in knee osteoarthritis: the infrapatellar fat pad
title_fullStr An emerging player in knee osteoarthritis: the infrapatellar fat pad
title_full_unstemmed An emerging player in knee osteoarthritis: the infrapatellar fat pad
title_short An emerging player in knee osteoarthritis: the infrapatellar fat pad
title_sort emerging player in knee osteoarthritis: the infrapatellar fat pad
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979009/
https://www.ncbi.nlm.nih.gov/pubmed/24367915
http://dx.doi.org/10.1186/ar4422
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