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Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT
Epithelial-mesenchymal transition (EMT) programs require the expression of a variety of so-called master regulators of EMT, including members of the Snail, Zeb, and Twist transcription factor families. Teleologically, the requirement for such a diverse group of ‘master regulators’ seems evolutionari...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979076/ https://www.ncbi.nlm.nih.gov/pubmed/23981787 http://dx.doi.org/10.1186/bcr3466 |
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author | Parvani, Jenny G Schiemann, William P |
author_facet | Parvani, Jenny G Schiemann, William P |
author_sort | Parvani, Jenny G |
collection | PubMed |
description | Epithelial-mesenchymal transition (EMT) programs require the expression of a variety of so-called master regulators of EMT, including members of the Snail, Zeb, and Twist transcription factor families. Teleologically, the requirement for such a diverse group of ‘master regulators’ seems evolutionarily cumbersome, and emerging evidence indicates that these transcription factors do in fact mediate unique and specialized functions, suggesting the existence of higher-order ‘masters’ that truly direct and coordinate EMT programs. Accordingly, Tiwari and colleagues recently delineated an elegant pathway wherein transforming growth factor-beta stimulates Sox4 expression, which induces that of the histone methyltransferase, Ezh2, thereby reprogramming the epigenome to elicit EMT programs and metastasis of breast cancers. This viewpoint highlights Sox4 as a ‘new’ master of EMT programs and metastatic breast cancer. |
format | Online Article Text |
id | pubmed-3979076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39790762014-04-08 Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT Parvani, Jenny G Schiemann, William P Breast Cancer Res Viewpoint Epithelial-mesenchymal transition (EMT) programs require the expression of a variety of so-called master regulators of EMT, including members of the Snail, Zeb, and Twist transcription factor families. Teleologically, the requirement for such a diverse group of ‘master regulators’ seems evolutionarily cumbersome, and emerging evidence indicates that these transcription factors do in fact mediate unique and specialized functions, suggesting the existence of higher-order ‘masters’ that truly direct and coordinate EMT programs. Accordingly, Tiwari and colleagues recently delineated an elegant pathway wherein transforming growth factor-beta stimulates Sox4 expression, which induces that of the histone methyltransferase, Ezh2, thereby reprogramming the epigenome to elicit EMT programs and metastasis of breast cancers. This viewpoint highlights Sox4 as a ‘new’ master of EMT programs and metastatic breast cancer. BioMed Central 2013 2013-08-27 /pmc/articles/PMC3979076/ /pubmed/23981787 http://dx.doi.org/10.1186/bcr3466 Text en Copyright © 2013 BioMed Central Ltd. |
spellingShingle | Viewpoint Parvani, Jenny G Schiemann, William P Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT |
title | Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT |
title_full | Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT |
title_fullStr | Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT |
title_full_unstemmed | Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT |
title_short | Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT |
title_sort | sox4, emt programs, and the metastatic progression of breast cancers: mastering the masters of emt |
topic | Viewpoint |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979076/ https://www.ncbi.nlm.nih.gov/pubmed/23981787 http://dx.doi.org/10.1186/bcr3466 |
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